NOAEL Studies Cosmetic Ingredient

Menthyl Acetate NOAEL Studies

INCI: MENTHYL ACETATE

CAS: 89-48-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =600 mg/kg bw/day Mouse oral: feed 721 days chronic/long term toxicity EFSA FEEDAP - 2016 - OutputID 2822 - mortality - systemic - Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4475
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =375 mg/kg bw/day Rat oral: feed 721 days chronic/long term toxicity EFSA FEEDAP - 2016 - OutputID 2822 - histopathology neoplastic - systemic - Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4475
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =600 mg/kg bw/day Mouse oral: feed 721 days chronic/long term toxicity EFSA FEEDAP - 2016 - OutputID 2822 - mortality - systemic - Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4475
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =375 mg/kg bw/day Rat oral: feed 721 days chronic/long term toxicity EFSA FEEDAP - 2016 - OutputID 2822 - histopathology neoplastic - systemic - Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4475
ToxValDB_EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =375 mg/kg bw/day Rat oral chronic; 103 weeks chronic LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4475.; TITLE=Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4475; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; STUDY_GROUP=EFSA:15624561:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a73f6b400ba1d8bfaba4717d236712b
ToxValDB_EFSA NOAEL =600 mg/kg bw/day Mouse oral chronic; 103 weeks chronic LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4475.; TITLE=Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4475; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EFSA:15624562:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_44e7e084aa37defa3e3a2b12a943ba6e
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =33.6 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633226:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f7288a7076776bd812dea3c212df0bd1
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier LF3LEI45OH UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LF3LEI45OH"}
openFDA substances FDA UNII substance identifier LF3LEI45OH UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LF3LEI45OH"}
openFDA substances FDA UNII substance identifier LF3LEI45OH UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LF3LEI45OH"}
openFDA substances FDA UNII substance identifier LF3LEI45OH UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H22O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LF3LEI45OH"}