Also known as: EINECS 285-377-1, Tea tree ext.
INCI: MELALEUCA ALTERNIFOLIA LEAF EXTRACT
Melaleuca Alternifolia Leaf Extract (CAS 85085-48-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning, fragrance, antimicrobial, antifungal, antioxidant. Reported NOAEL =45 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted, max 0.1% leave-on face cream; 1.0% rinse-off shower gel; 2.0% shampoo; sprays prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 85085-48-9 →
Melaleuca Alternifolia Leaf Extract is classified GHS Danger (H226, H302, H304, H315, H317, H319, H411) in the chemicals database but is restricted in EU cosmetics at max 0.1% leave-on face cream; 1.0% rinse-off shower gel; 2.0% shampoo; sprays prohibited.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Melaleuca Alternifolia Leaf Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
1 study endpoint found for Melaleuca Alternifolia Leaf Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =45 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Expert safety assessment and concern-level summary for Melaleuca Alternifolia Leaf Extract.
Public NOAEL study rows linked to Melaleuca Alternifolia Leaf Extract by CAS number or substance name.
Melaleuca Alternifolia Leaf Extract has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Melaleuca Alternifolia Leaf Extract EU regulatory status: restricted. Maximum allowed concentration: 0.1% leave-on face cream; 1.0% rinse-off shower gel; 2.0% shampoo; sprays prohibited. This is based on EU Regulation 1223/2009 and its amendments.
Melaleuca Alternifolia Leaf Extract functions as: Skin conditioning, fragrance, antimicrobial, antifungal, antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 85085-48-9.
The NOAEL (No Observed Adverse Effect Level) for Melaleuca Alternifolia Leaf Extract is =45 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Melaleuca Alternifolia Leaf Extract also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Melaleuca Alternifolia Leaf Extract is classified GHS Danger (H226, H302, H304, H315, H317, H319, H411) in the chemicals database but is restricted in EU cosmetics at max 0.1% leave-on face cream; 1.0% rinse-off shower gel; 2.0% shampoo; sprays prohibited.
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