What is the NOAEL for Melaleuca alternifolia, extract?
Melaleuca alternifolia, extract has 2 NOAEL studies in the database. The lowest reported value is 0.658 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Melaleuca alternifolia, extract
Also known as: EINECS 285-377-1, Tea tree ext.
CAS 85085-48-9
Melaleuca alternifolia, extract (CAS 85085-48-9) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Melaleuca Alternifolia Leaf Extract →
Cross-Vertical Regulatory Divergence
Melaleuca alternifolia, extract is classified GHS Danger (H226, H302, H304, H315, H317, H319, H411) in the chemicals database but is restricted in EU cosmetics at max 0.1% leave-on face cream; 1.0% rinse-off shower gel; 2.0% shampoo; sprays prohibited.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
2
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
5 fields
Name
Melaleuca alternifolia, extract
CAS Number
85085-48-9
DTXSID
DTXSID701036497
Synonyms
EINECS 285-377-1Tea tree ext.
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
19 records
AbrasiveBiocideAstringentDeodorizerHumectantSoftener and conditionerFlavouring and nutrientFragrancePharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 2 of 2 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =0.658 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =45 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 2 of 2 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Melaleuca alternifolia, ext. | 285-377-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
0.1% leave-on face cream; 1.0% rinse-off shower gel; 2.0% shampoo; sprays prohibited
Category
botanical
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Melaleuca alternifolia, extract?
Melaleuca alternifolia, extract appears on 1 regulatory/inventory list including Europe; Personal care. Source: EPA CPDat.
Is Melaleuca alternifolia, extract used in cosmetics?
Yes, Melaleuca alternifolia, extract is also indexed as a cosmetic ingredient under the name Melaleuca Alternifolia Leaf Extract. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Melaleuca alternifolia, extract come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Melaleuca alternifolia, extract have different safety status in cosmetics vs industrial chemicals?
Melaleuca alternifolia, extract is classified GHS Danger (H226, H302, H304, H315, H317, H319, H411) in the chemicals database but is restricted in EU cosmetics at max 0.1% leave-on face cream; 1.0% rinse-off shower gel; 2.0% shampoo; sprays prohibited.
Is Melaleuca alternifolia, extract used outside industrial chemicals?
Melaleuca alternifolia, extract also appears in cosmetics, food safety databases.