Is Malus Domestica Fruit Cell Culture Extract safe in cosmetics?
Malus Domestica Fruit Cell Culture Extract has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Active Ingredient
Malus Domestica Fruit Cell Culture Extract
INCI: MALUS DOMESTICA FRUIT CELL CULTURE EXTRACT
Malus Domestica Fruit Cell Culture Extract (CAS N/A) is a cosmetic active ingredient functioning as Swiss apple callus extract (Uttwiler Spätlauber); antioxidant; anti-wrinkle;. EU Regulation 1223/2009 status: permitted, max 0.4-2%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
View industrial chemical safety profile for CAS N/A →
Auto-generated CPSR Part A draft with source citations
Function
Swiss apple callus extract (Uttwiler Spätlauber); antioxidant; anti-wrinkle; phytochemical delivery via lecithin liposomes; anti-aging
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.4-2%
US US Status
permitted
US Notes
No FDA restriction. Anti-aging appearance claims cosmetic. No CIR review. Manufacturer clinical data only — no independent RCT.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Malus Domestica Fruit Cell Culture Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (10)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | banned | - | - |
| CN | banned | - | - |
| CN | banned | - | - |
| CN | banned | - | - |
| CN | banned | - | - |
| CN | banned | - | - |
| CN | banned | - | - |
| CN | banned | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Roberts Skin Permeation (Mendeley 2022)
MW: 266.4
Log Kow: 3.11
Log Kp: -2.5228787452803374
Log Jmax: -8.680069051827536
Source: Roberts_Cheruvu_Mendeley_2022
Additional Ingredient Properties
2 property records from structured ingredient metadata.
fermentation
{"cas_number": "proprietary", "ingredient_class": "plant_cell_culture", "production_organism": "plant_cell", "fermentation_type": "bioreactor culture", "substrate_feedstock": "plant tissue culture media", "bioactive_compounds_produced": "epigenetic factors, metabolites, phytocompounds, stem cell factors", "mechanism_of_action_skin": "stem cell protection, longevity signaling, anti-senescence", "sk…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "5", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv":…
Expert Verdict
Expert safety assessment and concern-level summary for Malus Domestica Fruit Cell Culture Extract.
Regulatory Flags
antioxidant
anti-wrinkle
liposome-delivered
plant-stem-cell
marketing-claims-misleading
manufacturer-evidence-only
phenolic-rich
botanically-derived
claims-accuracy-required
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Glucosylated steviol glycosides
E Number
E960d
ADI
4 mg/kg bw
Food Category
sweetener
Frequently Asked Questions
Is Malus Domestica Fruit Cell Culture Extract allowed in the EU?
Malus Domestica Fruit Cell Culture Extract EU regulatory status: permitted. Maximum allowed concentration: 0.4-2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Malus Domestica Fruit Cell Culture Extract do in cosmetics?
Malus Domestica Fruit Cell Culture Extract functions as: Swiss apple callus extract (Uttwiler Spätlauber); antioxidant; anti-wrinkle; phytochemical delivery via lecithin liposomes; anti-aging. It is classified as a Active Ingredient in our database. CAS number: N/A.
Is Malus Domestica Fruit Cell Culture Extract used outside cosmetics?
Malus Domestica Fruit Cell Culture Extract also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Malus Domestica Fruit Cell Culture Extract compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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