Is Magnolol safe in cosmetics?
Magnolol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Magnolol
Also known as: 5,5'-Diallyl-2,2'-dihydroxybiphenyl, NSC 293099, UNII-001E35HGVF
INCI: MAGNOLOL
Magnolol (CAS 528-43-8) is a cosmetic cosmetic ingredient functioning as Antioxidant, anti-inflammatory, skin brightening (tyrosinase inhibitor),. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 528-43-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Magnolol is classified GHS Danger (H315, H318, H319, H335, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant, anti-inflammatory, skin brightening (tyrosinase inhibitor), antimicrobial/antifungal
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol
InChIKey
VVOAZFWZEDHOOU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed. No prohibitions or restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Magnolol.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
4 property records from structured ingredient metadata.
acne
{"cas_number": "528-43-8", "anti_acne_mechanism": "antibacterial/anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "p_acnes_mic_ug_per_ml": "20-100", "sebum_reduction_pct_clinical": "5-10", "optimal_ph_for_efficacy": "5.0-7.0", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_d…
anti_aging
{"anti_aging_claim": "anti-inflammatory, antioxidant-protection", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "No", "placebo_controlled": "Yes", "published_journal…
anti_pollution
{"cas_number": "528-43-8", "ingredient_class": "AhR_antagonist", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5/PAH", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "…
antioxidant
{"cas_number": "528-43-8", "antioxidant_class": "polyphenol", "chemical_subclass": "biphenolic compound", "molecular_weight_daltons": "266.34", "orac_value_umol_te_per_g": "13200", "dpph_radical_scavenging_ic50_ug_per_ml": "15-26", "abts_trolox_equivalent": "not available", "singlet_oxygen_quenching": "not available", "superoxide_dismutase_mimetic": "not available", "hydroxyl_radical_scavenging": …
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (2)
JECFA Number
2023
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
MAGNOLOL | 2010 | No safety concern at current levels of intake when used as a flavouring agent | TRS 960-JECFA 73/114 | FAS 64-JECFA 73/207
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Bleaching agent
Flavouring and nutrient
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Magnolol.
Regulatory Flags
potential-allergen
fda_food_additive
jecfa_safe
Known Synonyms
5,5'-Diallyl-2,2'-dihydroxybiphenyl
NSC 293099
UNII-001E35HGVF
Chemical Function
Antioxidant
Bleaching agent
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MAGNOLOL
ChEMBL ID
CHEMBL180920
Frequently Asked Questions
Is Magnolol allowed in the EU?
Magnolol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Magnolol do in cosmetics?
Magnolol functions as: Antioxidant, anti-inflammatory, skin brightening (tyrosinase inhibitor), antimicrobial/antifungal. It is classified as a cosmetic ingredient in our database. CAS number: 528-43-8.
Is Magnolol used outside cosmetics?
Magnolol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Magnolol have different safety status in cosmetics vs industrial chemicals?
Magnolol is classified GHS Danger (H315, H318, H319, H335, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Magnolol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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