Is FISETIN safe in cosmetics?
FISETIN has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
FISETIN
Also known as: 5-18-05-00291, BOIS bleude honqrie, BRN 0292829, Cotinin, EINECS 208-434-4 (+2 more)
FISETIN (CAS 528-48-3) is a cosmetic cosmetic ingredient functioning as Colorant, Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 528-48-3 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant, Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one
InChIKey
XHEFDIBZLJXQHF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
acne
{"cas_number": "528-48-3", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
cost_pricing
{"cost_tier": "premium", "estimated_cost_per_kg_usd_low": "280", "estimated_cost_per_kg_usd_high": "520", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "medium", "primary_source_region": "China/India", "bulk_discount_threshold_kg": "5", "seasonal_price_variation": "medium", "commodity_or_specialty": "specialty", "substitute_ingredients": "Resve…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for FISETIN.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
5-18-05-00291
BOIS bleude honqrie
BRN 0292829
Cotinin
EINECS 208-434-4
3,7,3',4'-Tetrahydroxyflavone
UNII-OO2ABO9578
Chemical Function
Softener and conditioner
Dye
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
FISETIN
ChEMBL ID
CHEMBL31574
Max Phase
2
Frequently Asked Questions
Is FISETIN allowed in the EU?
FISETIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does FISETIN do in cosmetics?
FISETIN functions as: Colorant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 528-48-3.
Is FISETIN used outside cosmetics?
FISETIN also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check FISETIN compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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