Is Magnolia Officinalis Bark Extract safe in cosmetics?
Magnolia Officinalis Bark Extract has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Active Ingredient
Magnolia Officinalis Bark Extract
INCI: MAGNOLIA OFFICINALIS BARK EXTRACT
Magnolia Officinalis Bark Extract (CAS 947686-05-7) is a cosmetic active ingredient functioning as Antimicrobial, Skin Conditioning, Antioxidant, Anti-inflammatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 947686-05-7 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial, Skin Conditioning, Antioxidant, Anti-inflammatory
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol;2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
InChIKey
AHDXDAUDZWEXCN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No CIR safety assessment has been published for Magnolia Officinalis Bark Extract, magnolol, or honokiol. Not an OTC monograph ingredient; no GRASE classification applicable. Used in US cosmetics under general FD&C Act cosmetic regulations with no ingredient-specific FDA restrictions. MoCRA standard product listing requirements apply.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Magnolia Officinalis Bark Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
4 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "anti-inflammatory, antioxidant-protection", "mechanism_of_action": "Bioactive phytochemicals, antioxidant compounds", "target_skin_layer": "epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "6-12", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "Ph…
anti_pollution
{"cas_number": "528-43-8", "ingredient_class": "AhR_antagonist", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5/PAH", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "…
deodorant
{"cas_number": "528-43-8 (magnolol)", "ingredient_class": "antimicrobial_deodorant", "mechanism_of_action": "bacterial_growth_inhibition", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "8-16", "odor_reduction_pct": "55-75", "bacteriostatic": "yes", "bactericidal": "yes", "target_bacteria": "Corynebacterium/Staphylococcus", "microbiome_impact": "selective", "axilla…
depigmentation
{"cas_number": "not established", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Floral compounds provide antioxidant and anti-inflammatory brightening", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_…
Expert Verdict
Expert safety assessment and concern-level summary for Magnolia Officinalis Bark Extract.
Regulatory Flags
contact-dermatitis-reported
pigmented-contact-dermatitis
no-sccs-opinion
no-cir-assessment
no-noael-established
no-ript-data
no-phototoxicity-data
data-gap-significant
regulatory-grey-zone
Frequently Asked Questions
Is Magnolia Officinalis Bark Extract allowed in the EU?
Magnolia Officinalis Bark Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Magnolia Officinalis Bark Extract do in cosmetics?
Magnolia Officinalis Bark Extract functions as: Antimicrobial, Skin Conditioning, Antioxidant, Anti-inflammatory. It is classified as a Active Ingredient in our database. CAS number: 947686-05-7.
Is Magnolia Officinalis Bark Extract used outside cosmetics?
Magnolia Officinalis Bark Extract also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Magnolia Officinalis Bark Extract compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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