Is Mafenide HCl safe in cosmetics?
Mafenide HCl has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Mafenide HCl
Also known as: Ambamide hydrochloride, p-(Aminomethyl)benzenesulfonamide hydrochloride, 4-Aminomethylbenzenesulfonamide hydrochloride, p-(Aminomethyl)benzenesulfonamide monohydrochloride, p-Aminomethylphenylsulfonamide hydrochloride (+15 more)
INCI: MAFENIDE HCL
Mafenide HCl (CAS 138-37-4) is a cosmetic cosmetic ingredient functioning as Antimicrobial agent (sulfonamide-type). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 138-37-4 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial agent (sulfonamide-type)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-(aminomethyl)benzenesulfonamide;hydrochloride
InChIKey
SIACJRVYIPXFKS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA-approved as a prescription drug (topical burn treatment). Use in cosmetics would likely trigger drug classification under the FD&C Act if antimicrobial claims are made
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Mafenide HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Expert Verdict
Expert safety assessment and concern-level summary for Mafenide HCl.
Known Synonyms
Ambamide hydrochloride
p-(Aminomethyl)benzenesulfonamide hydrochloride
4-Aminomethylbenzenesulfonamide hydrochloride
p-(Aminomethyl)benzenesulfonamide monohydrochloride
p-Aminomethylphenylsulfonamide hydrochloride
alpha-Amino-p-toluenesulfonamide hydrochloride
EINECS 205-325-3
Emilene hydrochloride
Homosulfamine
Homosulfamine hydrochloride
Homosulfanilamide hydrochloride
4-Homosulfanilamide hydrochloride
Maphenide hydrochloride
Marfanil
Masudin
Mesudin hydrochloride
Mesudrin hydrochloride
Morfanil
Neofamid hydrochloride
NSC 3527
Chemical Function
Biocide
Regulatory Lists
active_ingredient; Australia
active_ingredient; Australia
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MAFENIDE HYDROCHLORIDE
ChEMBL ID
CHEMBL1593568
Max Phase
-1
Frequently Asked Questions
Is Mafenide HCl allowed in the EU?
Mafenide HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Mafenide HCl do in cosmetics?
Mafenide HCl functions as: Antimicrobial agent (sulfonamide-type). It is classified as a cosmetic ingredient in our database. CAS number: 138-37-4.
Is Mafenide HCl used outside cosmetics?
Mafenide HCl also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Mafenide HCl compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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