Is Lauramine Oxide safe in cosmetics?
Lauramine Oxide has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by cir.
Lauramine Oxide
Also known as: 1-Dodecanamine, N,N-dimethyl-, N-oxide, Lauryldimethylamine oxide, 4-04-00-00798, Amonyx AO, Aromox dmmc-W (+8 more)
INCI: LAURAMINE OXIDE
Lauramine Oxide (CAS 1643-20-5) is a cosmetic cosmetic ingredient functioning as Cleansing, emulsifying, foam boosting, surfactant. EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1643-20-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Lauramine Oxide is classified GHS Danger (H302, H315, H318, H400, H411, H412, H319, H410) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Cleansing, emulsifying, foam boosting, surfactant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
N,N-dimethyldodecan-1-amine oxide
InChIKey
SYELZBGXAIXKHU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no CFR prohibition; CIR Expert Panel concluded safe in rinse-off products; leave-on products limited to ≤3.7%
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Lauramine Oxide.
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: unknown
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
sensory
{"silky": "light", "smooth, glides easily": "rich, foam-boosting", "dry-touch, non-greasy": "clean, soft", "instant": "fast", "none": "high", "low": "low", "w/o": "o/w", "very-high": "high", "no": "no", "yes": "no", "1.40": "1.48", "transparent": "transparent", "colorless": "colorless", "excellent": "excellent", "light": "light", "synthetic": "synthetic"}
surfactant
{"cas_number": "1643-20-5", "surfactant_type": "amphoteric", "chemical_class": "amine_oxide", "charge_at_use_ph": "zwitterionic", "cmc_critical_micelle_concentration_mm": "0.09", "hlb_value": "19.0", "foam_volume_ml_ross_miles": "125", "foam_quality": "creamy", "foam_stability_5min_pct": "81", "cleansing_power_rating_1_to_10": "6.4", "oil_emulsification_capacity": "good", "sebum_removal_efficiency…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Cleaning agent
Emulsifier
Foamant
Fragrance
Softener and conditioner
Solubility enhancer
Stabilizing agent
Surfactant (surface active agent)
Thickening agent
Regulatory List Membership (2)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Lauramine Oxide.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
Known Synonyms
1-Dodecanamine, N,N-dimethyl-, N-oxide
Lauryldimethylamine oxide
4-04-00-00798
Amonyx AO
Aromox dmmc-W
BRN 1769927
1-Dodecanamine, N,N-dimethl-, N-oxide
Dodecyldimethylamine N-oxide
EINECS 216-700-6
NCI-C55129
N,N-Dimethyl-dodecylaminoxid
Oxyde de dimethyllaurylamine
UNII-4F6FC4MI8W
Chemical Function
Surfactant (surface active agent)
Solubility enhancer
Anti-static agent
Regulatory Lists
Canada; pharmaceutical
IFRA Transparency
SCIL (9/2019)
inert_ingredient; non_food_use; Pesticides
Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1233973
Frequently Asked Questions
Is Lauramine Oxide allowed in the EU?
Lauramine Oxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lauramine Oxide do in cosmetics?
Lauramine Oxide functions as: Cleansing, emulsifying, foam boosting, surfactant. It is classified as a cosmetic ingredient in our database. CAS number: 1643-20-5.
Is Lauramine Oxide used outside cosmetics?
Lauramine Oxide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Lauramine Oxide have different safety status in cosmetics vs industrial chemicals?
Lauramine Oxide is classified GHS Danger (H302, H315, H318, H400, H411, H412, H319, H410) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Lauramine Oxide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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