What is the NOAEL for N,N-Dimethyldodecylamine-N-oxide?
N,N-Dimethyldodecylamine-N-oxide has 17 NOAEL studies in the database. The lowest reported value is 6.2 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
N,N-Dimethyldodecylamine-N-oxide
Also known as: 1-Dodecanamine, N,N-dimethyl-, N-oxide, Lauryldimethylamine oxide, 4-04-00-00798, Amonyx AO, Aromox dmmc-W (+8 more)
CAS 1643-20-5
N,N-Dimethyldodecylamine-N-oxide (CAS 1643-20-5) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
N,N-Dimethyldodecylamine-N-oxide is classified GHS Danger (H302, H315, H318, H400, H411, H412, H319, H410) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
19 fields
Name
N,N-Dimethyldodecylamine-N-oxide
CAS Number
1643-20-5
DTXSID
DTXSID1020514
Molecular Formula
C14H31NO
InChI Key
SYELZBGXAIXKHU-UHFFFAOYSA-N
Monoisotopic Mass
229.240565
Synonyms
1-Dodecanamine, N,N-dimethyl-, N-oxideLauryldimethylamine oxide4-04-00-00798Amonyx AOAromox dmmc-WBRN 17699271-Dodecanamine, N,N-dimethl-, N-oxideDodecyldimethylamine N-oxideEINECS 216-700-6NCI-C55129N,N-Dimethyl-dodecylaminoxidOxyde de dimethyllaurylamine
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Surfactant (surface active agent)Solubility enhancerAnti-static agentFragranceViscosity modifierCleaning agentSoftener and conditionerFoamant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| IFRA Transparency | IFRA | IFRA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 240 | min | Breakthrough Time | Dermal | - | NTP_ICE_skin_irritation |
| =6.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4F6FC4MI8W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4F6FC4MI8W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4F6FC4MI8W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4F6FC4MI8W | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O155V51N2P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O155V51N2P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O155V51N2P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| O155V51N2P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1064 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3800 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >20000 | mg/kg bw | LD50 | oral | Rat (Female) | NTP_ICE_acute_oral |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =50 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 1.4 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
| 1.5 | kiloohms | TER | Dermal | - | NTP_ICE_skin_irritation |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dodecyldimethylamine oxide | 216-700-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Surfactant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL1233973
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include N,N-Dimethyldodecylamine-N-oxide?
N,N-Dimethyldodecylamine-N-oxide appears on 6 regulatory/inventory lists including Canada; pharmaceutical, IFRA Transparency, SCIL (9/2019), and 3 more. Source: EPA CPDat.
Is N,N-Dimethyldodecylamine-N-oxide used in cosmetics?
Yes, N,N-Dimethyldodecylamine-N-oxide is also indexed as a cosmetic ingredient under the name Lauramine Oxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for N,N-Dimethyldodecylamine-N-oxide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does N,N-Dimethyldodecylamine-N-oxide have different safety status in cosmetics vs industrial chemicals?
N,N-Dimethyldodecylamine-N-oxide is classified GHS Danger (H302, H315, H318, H400, H411, H412, H319, H410) in the chemicals database but is allowed in EU cosmetics.
Is N,N-Dimethyldodecylamine-N-oxide used outside industrial chemicals?
N,N-Dimethyldodecylamine-N-oxide also appears in cosmetics, pharmaceutical, cannabis databases.