Is Lactitol safe in cosmetics?
Lactitol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Lactitol
Also known as: EINECS 209-566-5, Lactitolum, UNII-L2B0WJF7ZY, D-lactitol
INCI: LACTITOL
Lactitol (CAS 585-86-4) is a cosmetic cosmetic ingredient functioning as Skin conditioning (humectant properties). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 585-86-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (humectant properties)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2S,3R,4R,5R)-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol
InChIKey
VQHSOMBJVWLPSR-JVCRWLNRSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FDA GRAS food additive; not restricted in cosmetics under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Lactitol.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Evaluation
LACTOSITOL | 1983 | NOT SPECIFIED | TRS 696-JECFA 27/23 | FAS 18-JECFA 27/82
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Lactitol.
Regulatory Flags
jecfa_safe
Known Synonyms
EINECS 209-566-5
Lactitolum
UNII-L2B0WJF7ZY
D-lactitol
Chemical Function
Humectant
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
LACTITOL
ChEMBL ID
CHEMBL1661
Max Phase
4
Adverse Event Associations
2
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Lactitol
E Number
E966
ADI
NOT SPECIFIED mg/kg bw
Food Category
sweetener
Frequently Asked Questions
Is Lactitol allowed in the EU?
Lactitol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lactitol do in cosmetics?
Lactitol functions as: Skin conditioning (humectant properties). It is classified as a cosmetic ingredient in our database. CAS number: 585-86-4.
Is Lactitol used outside cosmetics?
Lactitol also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Lactitol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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