Is Lactamide DEA safe in cosmetics?
Lactamide DEA has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Lactamide DEA
INCI: LACTAMIDE DEA
Lactamide DEA (CAS 5422-34-4) is a cosmetic cosmetic ingredient functioning as Emulsifier, humectant, surfactant. NOAEL 900 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 5422-34-4 →
Auto-generated CPSR Part A draft with source citations
Function
Emulsifier, humectant, surfactant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-hydroxy-N-(2-hydroxyethyl)propanamide
InChIKey
RZCHTMXTKQHYDT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted with CIR limitations — safe when formulated to be non-irritating; should not be used in products where N-nitroso compounds may form
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Lactamide DEA.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Lactamide DEA across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1774
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
N-LACTOYL ETHANOLAMINE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Flavouring and nutrient
Fragrance
Humectant
Softener and conditioner
Surfactant (surface active agent)
Thickening agent
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Lactamide DEA.
Regulatory Flags
ifra_fragrance
fda_food_additive
Chemical Function
Humectant
Anti-static agent
Softener and conditioner
Thickening agent
Surfactant (surface active agent)
Regulatory Lists
pharmaceutical
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Lactamide DEA allowed in the EU?
Lactamide DEA EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lactamide DEA do in cosmetics?
Lactamide DEA functions as: Emulsifier, humectant, surfactant. It is classified as a cosmetic ingredient in our database. CAS number: 5422-34-4.
Is Lactamide DEA used outside cosmetics?
Lactamide DEA also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Lactamide DEA compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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