Is Laccase safe in cosmetics?
Laccase has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Laccase
Laccase (CAS 80498-15-3) is a cosmetic cosmetic ingredient functioning as Oxidizing agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 80498-15-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Laccase is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Oxidizing agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-ethyl-2,5-dimethylpyrrole-3-carbaldehyde
InChIKey
NWDZDFOKSUDVJV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no specific cosmetic restriction under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Laccase.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health Hazard
Hazard Class and Category
Resp. Sens. 1
Hazard Statements
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
Inserted via ATP: ATP01
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Oxidizing agent
Expert Verdict
Expert safety assessment and concern-level summary for Laccase.
Regulatory Flags
potential-allergen
Chemical Function
Oxidizing agent
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Laccase allowed in the EU?
Laccase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Laccase do in cosmetics?
Laccase functions as: Oxidizing agent. It is classified as a cosmetic ingredient in our database. CAS number: 80498-15-3.
Is Laccase used outside cosmetics?
Laccase also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Laccase have different safety status in cosmetics vs industrial chemicals?
Laccase is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Laccase compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acrylates/Vinyl Neodecanoate Crosspolymer
Excellent
Same category
Emulsion stabilising, film forming
Adipic Acid
Excellent
Same category
Buffering
Aluminum Magnesium Oxide
Excellent
Same category
Absorbent, bulking agent, opacifying ...
Ammonium VA/Acrylates Copolymer
Excellent
Same category
Antistatic, binding, film forming, ha...
Ammonium VA/Crotonic Acid Copolymer
Excellent
Same category
Antistatic, film forming, hair fixing...
Aphanothece Sacrum Polysaccharide
Excellent
Same category
Absorbent, emulsion stabilising, film...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
LACTOBACCILLUS/HIBISCUS SABDARIFFA CALLUS CULTURE FERMENT FILTRATE
Good
Browse nearby
Antimicrobial, Antioxidant, Humectant...
LACTOBACILLUS/(ANGELICA ACUTILOBA/CNIDIUM OFFICINALE/GLYCYRRHIZA GLABRA/PAEONIA ALBIFLORA) ROOT/ SCHISANDRA CHINENSIS FRUIT FERMENT EXTRACT FILTRATE
Good
Browse nearby
Skin Conditioning
LACTOBACILLUS/(ASPARAGUS COCHINCHINENSIS/LYCIUM CHINENSE/OPHIOPOGON JAPONICUS/PANAX GINSENG/REHMANNIA GLUTINOSA) ROOT/PORIA COCOS FERMENT FILTRATE
Good
Browse nearby
Skin Conditioning
Is Laccase in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Laccase in your formulation.