What is the GHS hazard classification for Laccase?
Laccase (CAS 80498-15-3) is classified under EU CLP Annex VI as Resp. Sens. 1 with signal word Danger. Hazard statements: H334. Source: EU CLP Annex VI (ECHA).
Danger
GHS08
NOAEL Data
REACH Registered
Cosmetic Ingredient
Laccase
CAS 80498-15-3
Laccase (CAS 80498-15-3) is a chemical substance with GHS signal word Danger; key hazard signal: H334. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Laccase is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: eu_clp_annex_vi.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
2
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Danger
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
3 fields
Name
Laccase
CAS Number
80498-15-3
DTXSID
DTXSID30108720
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Resp. Sens. 1 | H334 | GHS08 | Danger |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Oxidizing agent
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 2 of 2 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| >=1720 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=1756 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 2 of 2 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Laccase | 420-150-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Frequently Asked Questions
What is the NOAEL for Laccase?
Laccase has 2 NOAEL studies in the database. The lowest reported value is 1720 mg/kg bw/day via oral in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Laccase used in cosmetics?
Yes, Laccase is also indexed as a cosmetic ingredient under the name Laccase. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Laccase come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Laccase have different safety status in cosmetics vs industrial chemicals?
Laccase is classified GHS Danger (H334) in the chemicals database but is allowed in EU cosmetics.
Is Laccase used outside industrial chemicals?
Laccase also appears in cosmetics databases.