Is L-Valine safe in cosmetics?
L-Valine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Antioxidant
L-Valine
INCI: VALINE
L-Valine (CAS 72-18-4) is a cosmetic antioxidant functioning as Essential branched-chain amino acid that inhibits lipid peroxidation and. NOAEL 628 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 72-18-4 →
Auto-generated CPSR Part A draft with source citations
Function
Essential branched-chain amino acid that inhibits lipid peroxidation and enhances the accessibility of fat-soluble reactive oxygen species (ROS) for scavenging. The hydrophobic branched-chain side chain of valine partitions into lipid-rich environments (sebum, membrane bilayers), enabling antioxidant protection in the lipid phase of the skin. Component of the free amino acid antioxidant pool.
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2S)-2-amino-3-methylbutanoic acid
InChIKey
KZSNJWFQEVHDMF-BYPYZUCNSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA GRAS as direct food additive. CIR amino acid class assessed safe.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for L-Valine.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for L-Valine across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
acne
{"cas_number": "72-18-4", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_ac…
anti_aging
{"anti_aging_claim": "barrier-repair", "mechanism_of_action": "Building block for proteins, NMF component", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "4-8", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Int J Cosmet Sci", "improvement_…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Regulatory List Membership (2)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for L-Valine.
Regulatory Flags
gras-fda
cir-approved
antioxidant
lipid-peroxidation-inhibitor
branched-chain
fda_food_additive
Chemical Function
No specific technical function
Flavouring and nutrient
Fragrance
Regulatory Lists
Australia; Food and drug - smoking-related products
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
VALINE
ChEMBL ID
CHEMBL43068
Max Phase
2
Adverse Event Associations
2
Frequently Asked Questions
Is L-Valine allowed in the EU?
L-Valine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Valine do in cosmetics?
L-Valine functions as: Essential branched-chain amino acid that inhibits lipid peroxidation and enhances the accessibility of fat-soluble reactive oxygen species (ROS) for scavenging. The hydrophobic branched-chain side chain of valine partitions into lipid-rich environments (sebum, membrane bilayers), enabling antioxidant protection in the lipid phase of the skin. Component of the free amino acid antioxidant pool.. It is classified as a Antioxidant in our database. CAS number: 72-18-4.
Is L-Valine used outside cosmetics?
L-Valine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check L-Valine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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