Is L-Arginine safe in cosmetics?
L-Arginine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Active Ingredient
L-Arginine
INCI: ARGININE
L-Arginine (CAS 74-79-3) is a cosmetic active ingredient functioning as Nitric oxide precursor; improves microcirculation, nutrient delivery, wound. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 74-79-3 →
Auto-generated CPSR Part A draft with source citations
Function
Nitric oxide precursor; improves microcirculation, nutrient delivery, wound healing, and barrier restoration. Ion-pair formulations with glutamic acid enhance percutaneous absorption.
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Classified GRAS by FDA as a direct food additive. CIR Expert Panel found safe as used in cosmetics.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for L-Arginine.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for L-Arginine.
Regulatory Flags
eu_children_restricted
fda_food_additive
jecfa_safe
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ARGININE
ChEMBL ID
CHEMBL1485
Max Phase
3
Adverse Event Associations
184
Frequently Asked Questions
Is L-Arginine allowed in the EU?
L-Arginine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Arginine do in cosmetics?
L-Arginine functions as: Nitric oxide precursor; improves microcirculation, nutrient delivery, wound healing, and barrier restoration. Ion-pair formulations with glutamic acid enhance percutaneous absorption.. It is classified as a Active Ingredient in our database. CAS number: 74-79-3.
Is L-Arginine used outside cosmetics?
L-Arginine also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check L-Arginine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Is L-Arginine in Your Products?
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