What is the NOAEL for L-Arginine?
L-Arginine has 10 NOAEL studies in the database. The lowest reported value is 552 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Arginine
Also known as: Arginine, Arginine, L-, 4-04-00-02648, (S)-2-Amino-5-((aminoiminomethyl)amino)pentanoic acid, 1-Amino-4-guanidovaleric acid (+15 more)
CAS 74-79-3
L-Arginine (CAS 74-79-3) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
L-Arginine
CAS Number
74-79-3
DTXSID
DTXSID6041056
Molecular Formula
C6H14N4O2
InChI Key
ODKSFYDXXFIFQN-BYPYZUCNSA-N
Monoisotopic Mass
174.111676
Synonyms
ArginineArginine, L-4-04-00-02648(S)-2-Amino-5-((aminoiminomethyl)amino)pentanoic acid1-Amino-4-guanidovaleric acid(L)-ArginineBRN 1725413EINECS 200-811-1L-Norvaline, 5-((aminoiminomethyl)amino)-Pentanoic acid, 2-amino-5-((aminoiminomethyl)amino)-, (S)-ArgininumUNII-94ZLA3W45F
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
19 records
Anti-static agentDeodorizerSoftener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =552 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 94ZLA3W45F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 94ZLA3W45F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 94ZLA3W45F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 94ZLA3W45F | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =3.131 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =3.131 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =3.131 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 50 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 174 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Arginine | 200-811-1 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ARGININE
ChEMBL Phase
3
Adverse Events
184
Bioactivity
8
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
FDA GRAS: FDA has no questions
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Arginine?
L-Arginine appears on 7 regulatory/inventory lists including pharmaceutical, children; Europe; Personal care, children; Europe; Personal care - general moisturizing - hand/body lotion, and 4 more. Source: EPA CPDat.
Is L-Arginine used in cosmetics?
Yes, L-Arginine is also indexed as a cosmetic ingredient under the name Arginine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Arginine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Arginine used outside industrial chemicals?
L-Arginine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.