Is Kojic Dipalmitate safe in cosmetics?
Kojic Dipalmitate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Kojic Dipalmitate
INCI: KOJIC DIPALMITATE
Kojic Dipalmitate (CAS 79725-98-7) is a cosmetic active ingredient functioning as Lipophilic dipalmitoyl ester of kojic acid. Converted to free kojic acid by. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 79725-98-7 →
Auto-generated CPSR Part A draft with source citations
Function
Lipophilic dipalmitoyl ester of kojic acid. Converted to free kojic acid by cutaneous esterases after penetration. Greater photostability and formulation stability than parent kojic acid. Reduced sensitization risk at equivalent brightening doses. Preferred alternative to kojic acid for leave-on formulations and sensitive skin. Tyrosinase inhibitor and radiance active.
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted without restriction. Not listed under Annex III, which covers kojic acid only. Ester pro-drug of kojic acid with reduced systemic exposure versus parent compound. MoCRA safety substantiation required.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Kojic Dipalmitate.
Calculate MoS for your specific formulation with the MoS Calculator.
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.5–2 | 3 | Industry |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
depigmentation
{"cas_number": "79725-98-7", "ingredient_class": "tyrosinase_inhibitor", "primary_mechanism_of_action": "Lipophilic ester releasing kojic acid in skin; improved stability vs kojic acid", "secondary_mechanisms": "Enhanced skin penetration via lipophilicity", "molecular_target": "tyrosinase", "tyrosinase_inhibition_IC50_uM": "8.5-12.0", "tyrosinase_inhibition_type": "copper_chelation", "melanin_redu…
skin_brightening
{"cas_number": "79725-98-7", "mechanism_of_action": "Tyrosinase inhibition (lipophilic prodrug)", "melanogenesis_pathway_target": "Tyrosinase", "tyrosinase_inhibition_ic50_um": "~70 (after conversion)", "tyrosinase_inhibition_vs_kojic_acid": "Similar to kojic acid", "melanosome_transfer_inhibitor": "Partial", "melanin_oxidation_reducer": "Yes", "endothelin_pathway_blocker": "No", "alpha_msh_antago…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Kojic Dipalmitate.
Regulatory Flags
hyperpigmentation
tyrosinase-inhibitor
radiance
fermented-source
improved-stability
lower-sensitization
Chemical Function
Softener and conditioner
Frequently Asked Questions
Is Kojic Dipalmitate allowed in the EU?
Kojic Dipalmitate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Kojic Dipalmitate do in cosmetics?
Kojic Dipalmitate functions as: Lipophilic dipalmitoyl ester of kojic acid. Converted to free kojic acid by cutaneous esterases after penetration. Greater photostability and formulation stability than parent kojic acid. Reduced sensitization risk at equivalent brightening doses. Preferred alternative to kojic acid for leave-on formulations and sensitive skin. Tyrosinase inhibitor and radiance active.. It is classified as a Active Ingredient in our database. CAS number: 79725-98-7.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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