Is Isopulegyl Acetate safe in cosmetics?
Isopulegyl Acetate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Isopulegyl Acetate
Also known as: Cyclohexanol, 5-methyl-2-(1-methylethenyl)-, 1-acetate, (1R,2S,5R)-, Cyclohexanol, 5-methyl-2-(1-methylethenyl)-, acetate, (1R,2S,5R)-
INCI: ISOPULEGYL ACETATE
Isopulegyl Acetate (CAS 57576-09-7) is a cosmetic cosmetic ingredient functioning as Fragrance (perfuming agent). EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 57576-09-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isopulegyl Acetate is classified GHS Danger (H351, H372) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance (perfuming agent)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
[(1R,2S,5R)-5-methyl-2-prop-1-en-2-ylcyclohexyl] acetate
InChIKey
HLHIVJRLODSUCI-ADEWGFFLSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Allowed - no specific prohibition or restriction.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopulegyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5184 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
756
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOPULEGYL ACETATE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/56 | FAS 46-JECFA 55/221
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Isopulegyl Acetate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
jecfa_safe
Known Synonyms
Cyclohexanol, 5-methyl-2-(1-methylethenyl)-, 1-acetate, (1R,2S,5R)-
Cyclohexanol, 5-methyl-2-(1-methylethenyl)-, acetate, (1R,2S,5R)-
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3120645
Frequently Asked Questions
Is Isopulegyl Acetate allowed in the EU?
Isopulegyl Acetate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopulegyl Acetate do in cosmetics?
Isopulegyl Acetate functions as: Fragrance (perfuming agent). It is classified as a cosmetic ingredient in our database. CAS number: 57576-09-7.
Is Isopulegyl Acetate used outside cosmetics?
Isopulegyl Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isopulegyl Acetate have different safety status in cosmetics vs industrial chemicals?
Isopulegyl Acetate is classified GHS Danger (H351, H372) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Isopulegyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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