Is Isophorone Diamine safe in cosmetics?
Isophorone Diamine has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Isophorone Diamine
Also known as: 3-Aminomethyl-3,5,5-trimethyl-cyclohexylamine, EINECS 220-666-8
INCI: ISOPHORONE DIAMINE
Isophorone Diamine (CAS 2855-13-2) is a cosmetic cosmetic ingredient functioning as Not reported for cosmetic use (industrial epoxy curing agent). NOAEL 100 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 2855-13-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isophorone Diamine is classified GHS Danger (H302, H312, H314, H317, H318, H412, H373, H402) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Not reported for cosmetic use (industrial epoxy curing agent)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
3-(aminomethyl)-3,5,5-trimethylcyclohexan-1-amine
InChIKey
RNLHGQLZWXBQNY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not on FDA prohibited/restricted lists; no specific CFR citation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isophorone Diamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Isophorone Diamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | oral | Rat | acute | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
CorrExcl markWarn
Hazard Statements
Harmful if swallowed Causes severe skin burns and eye damage May cause an allergic skin reaction Harmful to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of high concentrations may cause lung oedema, but only after initial corrosive effects on the eyes and the upper respiratory tract have become manifest. Medical observation is indicated.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.
Routes of Exposure
Serious local effects by all routes of exposure.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Isophorone Diamine across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantCorrosive
Hazard Class and Category
Acute Tox. 4; Skin Corr. 1B; Eye Dam. 1; Skin Sens. 1A
Hazard Statements
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
- H318 Causes serious eye damage
- H317 May cause an allergic skin reaction
Specific Concentration Limits / M-factors
oral: ATE = 1030.0 mg/kg bw; Skin Sens. 1A; H317: C ≥ 0.001%
Inserted via ATP: ATP17
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0498
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Chemical reaction regulator
Corrosion inhibitor
Hardener
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Isophorone Diamine.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Isophorone Diamine by CAS number or substance name.
Studies
2
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
3-Aminomethyl-3,5,5-trimethyl-cyclohexylamine
EINECS 220-666-8
Chemical Function
Binder
Hardener
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
CEDI
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Isophorone Diamine allowed in the EU?
Isophorone Diamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isophorone Diamine do in cosmetics?
Isophorone Diamine functions as: Not reported for cosmetic use (industrial epoxy curing agent). It is classified as a cosmetic ingredient in our database. CAS number: 2855-13-2.
What is the NOAEL for Isophorone Diamine?
The NOAEL (No Observed Adverse Effect Level) for Isophorone Diamine is =50 mg/kg bw/day based on a developmental study via oral route in Rabbit. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Isophorone Diamine classified as hazardous under GHS?
Isophorone Diamine carries a GHS signal word of "DANGER". Hazard statements: Harmful if swallowed Causes severe skin burns and eye damage May cause an allergic skin reaction Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Isophorone Diamine used outside cosmetics?
Isophorone Diamine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isophorone Diamine have different safety status in cosmetics vs industrial chemicals?
Isophorone Diamine is classified GHS Danger (H302, H312, H314, H317, H318, H412, H373, H402) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Isophorone Diamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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