Is Isolongifolanone safe in cosmetics?
Isolongifolanone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Isolongifolanone
Also known as: EINECS 245-890-3, Isolongifolene ketone, 2H-2,4a-Methanonaphthalen-8(5H)-one, hexahydro-1,1,5,5-tetramethyl-, (2alpha,4aalpha,8abeta)-, 2,2,7,7-Tetramethyltricyclo(6.2.1.0(1,6))-undecan-5-one
INCI: ISOLONGIFOLANONE
Isolongifolanone (CAS 23787-90-8) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 23787-90-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isolongifolanone is classified GHS CMR hazard (H315, H317, H411, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2,2,8,8-tetramethyl-octahydro-1H-2,4a-methanonapthalen-10-one
InChIKey
VCOCESNMLNDPLX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isolongifolanone.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
2700 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [450] RIFM (1977): RIFM report number 7835, September 20, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 110 | 0 | 9093 | 9093 | non-sensitizer |
| HMT | - | 0 | 2700 | - | - |
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Isolongifolanone.
Regulatory Flags
fragrance-component
ifra_fragrance
Known Synonyms
EINECS 245-890-3
Isolongifolene ketone
2H-2,4a-Methanonaphthalen-8(5H)-one, hexahydro-1,1,5,5-tetramethyl-, (2alpha,4aalpha,8abeta)-
2,2,7,7-Tetramethyltricyclo(6.2.1.0(1,6))-undecan-5-one
Chemical Function
Fragrance
Regulatory Lists
consumer_product
IFRA Transparency
IFRA Transparency
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Isolongifolanone allowed in the EU?
Isolongifolanone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isolongifolanone do in cosmetics?
Isolongifolanone functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 23787-90-8.
Is Isolongifolanone used outside cosmetics?
Isolongifolanone also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isolongifolanone have different safety status in cosmetics vs industrial chemicals?
Isolongifolanone is classified GHS CMR hazard (H315, H317, H411, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Isolongifolanone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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