Is Isobutyl Acetate safe in cosmetics?
Isobutyl Acetate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Isobutyl Acetate
Also known as: Acetic acid, 2-methylpropyl ester, 4-02-00-00149, BRN 1741909, EINECS 203-745-1, FEMA No. 2175 (+9 more)
Isobutyl Acetate (CAS 110-19-0) is a cosmetic cosmetic ingredient functioning as Flavouring and nutrient; Fragrance; No specific technical function; Solvent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 110-19-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isobutyl Acetate is classified GHS Danger (H225, H336, H316, H320, H333) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Flavouring and nutrient; Fragrance; No specific technical function; Solvent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2-methylpropyl acetate
InChIKey
GJRQTCIYDGXPES-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS (No. 2175); no CFR restriction for cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isobutyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The vapour is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance_ifra
{"cas_number": "110-19-0", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.14", "ifra_max_use_level_category_4_pct": "2.2", "ifra_max_use_level_category_7_pct": "0.32", "ifra_max_use_level_category_11_pct": "0.065", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_po…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0494
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
137
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOBUTYL ACETATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Solvent
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Isobutyl Acetate.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Isobutyl Acetate by CAS number or substance name.
Studies
9
Lowest NOAEL
316 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Acetic acid, 2-methylpropyl ester
4-02-00-00149
BRN 1741909
EINECS 203-745-1
FEMA No. 2175
FEMA Number 2175
beta-Methylpropyl ethanoate
Isobutylester kyseliny octove
UNII-7CR47FO6LF
2-methylpropyl ethanoate
Essigsaeureisobutylester
Isobutylazetat
i-butyl acetate
isobutyl ethanoate
Chemical Function
Solvent
Fragrance
No specific technical function
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australia; Food and drug - smoking-related products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ACETIC ACID ISOBUTYL ESTER
ChEMBL ID
CHEMBL46999
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ISOBUTYL ACETATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Isobutyl Acetate allowed in the EU?
Isobutyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutyl Acetate do in cosmetics?
Isobutyl Acetate functions as: Flavouring and nutrient; Fragrance; No specific technical function; Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 110-19-0.
Is Isobutyl Acetate used outside cosmetics?
Isobutyl Acetate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isobutyl Acetate have different safety status in cosmetics vs industrial chemicals?
Isobutyl Acetate is classified GHS Danger (H225, H336, H316, H320, H333) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Isobutyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Similar safety
Skin conditioning (skin brightening/l...
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
Excellent
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
Excellent
Similar safety
Antioxidant; tyrosinase inhibitor; me...
3-Glyceryl Ascorbate
Excellent
Similar safety
Antioxidant, Humectant, Skin Conditio...
3-Hydroxybutyrate/3-Hydroxyhexanoate Copolymer
Excellent
Similar safety
Film Forming, Viscosity Controlling, ...
1,4-Butanediol
Poor
Chemical family
Solvent, humectant, viscosity control...
2-Ethoxyethanol
Poor
Chemical family
Solvent
2-Methyldodecanal
Moderate
Chemical family
Fragrance ingredient with aldehydic, ...
Is Isobutyl Acetate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Isobutyl Acetate in your formulation.