Is Indigofera Tinctoria Leaf safe in cosmetics?
Indigofera Tinctoria Leaf has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Indigofera Tinctoria Leaf
Also known as: EINECS 283-892-6, Indigofera tinctoria
INCI: INDIGOFERA TINCTORIA LEAF
Indigofera Tinctoria Leaf (CAS 84775-63-3) is a cosmetic cosmetic ingredient functioning as Hair colorant, skin conditioning. Reported NOAEL =0.87 mg/kg bw in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 84775-63-3 →
Auto-generated CPSR Part A draft with source citations
Function
Hair colorant, skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
283-892-6
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — not specifically restricted under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Indigofera Tinctoria Leaf.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Indigofera Tinctoria Leaf. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.87 mg/kg bw | oral | rat | carcinogenicity | SCCS_vision_codex |
| NOAEL | =0.87 mg/kg bw | oral | rat | carcinogenicity | SCCS_vision_codex |
| NOAEL | =0.87 mg/kg bw | oral | rat | carcinogenicity | SCCS_vision_codex |
| NOAEL | =0.87 mg/kg bw | oral | rat | carcinogenicity | SCCS_vision_codex |
| NOAEL | =8.7 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =8.7 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =8.7 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =8.7 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =40 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =40 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: Restricted. Max: 비산화염모제에 25%. 기타제품에 사용금지
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products.. Max: As from 3 June 2021: 25 %..
BRIN Brazil/India Cosmetics
India: Restricted · max As from 3 June 2021: 25 %.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Humectant
No specific technical function
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Indigofera Tinctoria Leaf.
Regulatory Flags
colorant
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Indigofera Tinctoria Leaf by CAS number or substance name.
Studies
12
Lowest NOAEL
0.87 mg/kg bw
Highest NOAEL
40 mg/kg bw
SCCS_vision_codex
Known Synonyms
EINECS 283-892-6
Indigofera tinctoria
Chemical Function
Deodorizer
Humectant
Softener and conditioner
No specific technical function
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Indigofera Tinctoria Leaf allowed in the EU?
Indigofera Tinctoria Leaf EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Indigofera Tinctoria Leaf do in cosmetics?
Indigofera Tinctoria Leaf functions as: Hair colorant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 84775-63-3.
What is the NOAEL for Indigofera Tinctoria Leaf?
The NOAEL (No Observed Adverse Effect Level) for Indigofera Tinctoria Leaf is =0.87 mg/kg bw based on a carcinogenicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is Indigofera Tinctoria Leaf used outside cosmetics?
Indigofera Tinctoria Leaf also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Indigofera Tinctoria Leaf compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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