Is Ibuprofen safe in cosmetics?
Ibuprofen has a safety rating of "POOR" in our database. EU status: prohibited. US status: prohibited.
Poor
Cosmetic Ingredient
Ibuprofen
INCI: IBUPROFEN
Ibuprofen (CAS 15687-27-1 [^1_9]) is a cosmetic cosmetic ingredient functioning as Anti-inflammatory (pharmaceutical active — NSAID). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 15687-27-1 [^1_9] →
Auto-generated CPSR Part A draft with source citations
Function
Anti-inflammatory (pharmaceutical active — NSAID)
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Drug ingredient — regulated under OTC Drug Monograph (21 CFR 201); not a permitted cosmetic ingredient without drug classification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ibuprofen.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Ibuprofen.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ibuprofen by CAS number or substance name.
Studies
28
Lowest NOAEL
1 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Frequently Asked Questions
Is Ibuprofen allowed in the EU?
Ibuprofen EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Ibuprofen do in cosmetics?
Ibuprofen functions as: Anti-inflammatory (pharmaceutical active — NSAID). It is classified as a cosmetic ingredient in our database. CAS number: 15687-27-1 [^1_9].
Compliance Tools
Check Ibuprofen compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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