Is Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) safe in cosmetics?
Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES)
Also known as: HEPES, 5-23-02-00379, BRN 0883043, EINECS 230-907-9, N-2-Hydroxyethylpiperazine N',2'-ethanesulfonic acid (+7 more)
Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) (CAS 7365-45-9) is a cosmetic cosmetic ingredient functioning as pH regulating agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7365-45-9 →
Auto-generated CPSR Part A draft with source citations
Function
pH regulating agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
InChIKey
JKMHFZQWWAIEOD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES).
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
8 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| NOEL | =1000 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOEL | =1000 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOEL | =1000 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
| NOEL | =1000 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES).
Known Synonyms
HEPES
5-23-02-00379
BRN 0883043
EINECS 230-907-9
N-2-Hydroxyethylpiperazine N',2'-ethanesulfonic acid
N-2-Hydroxyethylpiperazine-N-ethane sulfonic acid
4-(2-Hydroxyethyl)-1-piperazineethane sulfonic acid
N-2-Hydroxyethylpiperazine-N'-ethanesulfonate
N-2-Hydroxyethylpiperazine-N'-ethanesulfonic acid
UNII-RWW266YE9I
2-[4-(2-hydroxyethyl)-2,3,5,6-tetrahydropyrazin-1-yl]ethanesulfonate
2-[4-(2-hydroxyethyl)piperazin-4-ium-1-yl]ethanesulfonate
Chemical Function
pH regulating agent
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1232545
Frequently Asked Questions
Is Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) allowed in the EU?
Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) do in cosmetics?
Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) functions as: pH regulating agent. It is classified as a cosmetic ingredient in our database. CAS number: 7365-45-9.
Is Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) used outside cosmetics?
Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID
Good
Chemical family
Buffering
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