NOAEL Studies
Cosmetic Ingredient
Houttuynia Cordata Leaf/Stem Extract NOAEL Studies
INCI: HOUTTUYNIA CORDATA LEAF/STEM EXTRACT
CAS: 164288-50-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR_vision_codex 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR_vision_codex | NOAEL | =250 | mg/kg/d | rat | oral | Subchronic | repeated dose toxicity | {"citation":"5; 28; (6","dose":"Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5.","effect":"dominal muscle contraction, and fatigue, but no mortality or other significant changes. Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5. A 28-d toxicity study conducted in Sprague-Dawley rats (6/sex/group) treated with an ethanolic extract of Houttuynia cordata (250 - 1000 mg/kg/d) resulted in some mortality and several signs of liver and kidney toxicity in the higher dose groups.16 The no- observed-adverse-effect-level (NOAEL) was concluded to be 250 mg/kg/d. Another short-term toxicity study conducted in rabbits (strain not stated; 6/group) given an ethanolic extract of Houttuynia cordata (up to 1500 mg/kg bw/d) for 28 d reported no significant changes or signs of toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducte...","page":5,"pdf":"SLR_HouttuyniaCordata_122025.pdf","row_type":"noael_study","study_id":"SLR_HouttuyniaCordata_122025_noael_001"} |
| CIR_vision_codex | NOAEL | =350 | mg/kg/d | rat | - | 2-wk | developmental toxicity | {"citation":"17; 2; (6","dose":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/g...","effect":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/group) given the same doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%) resulted in several signs of kidney toxicity in the higher dose groups. The NOAEL was determined to be 350 mg/kg/d for female rats and 999 mg/kg/d for male rats. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES In Vitro Houttuynia Cordata Extract Embryoid bodies were generated from human-induced pluripotent stem cells (hiPSCs) and placed in aqueous Houttuynia cordata extract concentrations of 0, 150, 250, and 350 μg/ml, and observed for 4 d (mifepristone used as positive control; replicated 3 times).19 At all extract concentrations, embryoid bodies were significantly smaller in diameter than the","page":5,"pdf":"SLR_HouttuyniaCordata_122025.pdf","row_type":"noael_study","study_id":"SLR_HouttuyniaCordata_122025_noael_002"} |
| CIR_vision_codex | NOAEL | =250 | mg/kg/d | rat | oral | Subchronic | repeated dose toxicity | {"citation":"5; 28; (6","dose":"Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5.","effect":"dominal muscle contraction, and fatigue, but no mortality or other significant changes. Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5. A 28-d toxicity study conducted in Sprague-Dawley rats (6/sex/group) treated with an ethanolic extract of Houttuynia cordata (250 - 1000 mg/kg/d) resulted in some mortality and several signs of liver and kidney toxicity in the higher dose groups.16 The no- observed-adverse-effect-level (NOAEL) was concluded to be 250 mg/kg/d. Another short-term toxicity study conducted in rabbits (strain not stated; 6/group) given an ethanolic extract of Houttuynia cordata (up to 1500 mg/kg bw/d) for 28 d reported no significant changes or signs of toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducte...","page":5,"pdf":"SLR_HouttuyniaCordata_122025.pdf","row_type":"noael_study","study_id":"SLR_HouttuyniaCordata_122025_noael_001"} |
| CIR_vision_codex | NOAEL | =350 | mg/kg/d | rat | - | 2-wk | developmental toxicity | {"citation":"17; 2; (6","dose":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/g...","effect":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/group) given the same doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%) resulted in several signs of kidney toxicity in the higher dose groups. The NOAEL was determined to be 350 mg/kg/d for female rats and 999 mg/kg/d for male rats. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES In Vitro Houttuynia Cordata Extract Embryoid bodies were generated from human-induced pluripotent stem cells (hiPSCs) and placed in aqueous Houttuynia cordata extract concentrations of 0, 150, 250, and 350 μg/ml, and observed for 4 d (mifepristone used as positive control; replicated 3 times).19 At all extract concentrations, embryoid bodies were significantly smaller in diameter than the","page":5,"pdf":"SLR_HouttuyniaCordata_122025.pdf","row_type":"noael_study","study_id":"SLR_HouttuyniaCordata_122025_noael_002"} |
| CIR_vision_codex | NOAEL | =250 | mg/kg/d | rat | oral | Subchronic | repeated dose toxicity | {"citation":"5; 28; (6","dose":"Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5.","effect":"dominal muscle contraction, and fatigue, but no mortality or other significant changes. Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5. A 28-d toxicity study conducted in Sprague-Dawley rats (6/sex/group) treated with an ethanolic extract of Houttuynia cordata (250 - 1000 mg/kg/d) resulted in some mortality and several signs of liver and kidney toxicity in the higher dose groups.16 The no- observed-adverse-effect-level (NOAEL) was concluded to be 250 mg/kg/d. Another short-term toxicity study conducted in rabbits (strain not stated; 6/group) given an ethanolic extract of Houttuynia cordata (up to 1500 mg/kg bw/d) for 28 d reported no significant changes or signs of toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducte...","page":5,"pdf":"SLR_HouttuyniaCordata_122025.pdf","row_type":"noael_study","study_id":"SLR_HouttuyniaCordata_122025_noael_001"} |
| CIR_vision_codex | NOAEL | =350 | mg/kg/d | rat | - | 2-wk | developmental toxicity | {"citation":"17; 2; (6","dose":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/g...","effect":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/group) given the same doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%) resulted in several signs of kidney toxicity in the higher dose groups. The NOAEL was determined to be 350 mg/kg/d for female rats and 999 mg/kg/d for male rats. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES In Vitro Houttuynia Cordata Extract Embryoid bodies were generated from human-induced pluripotent stem cells (hiPSCs) and placed in aqueous Houttuynia cordata extract concentrations of 0, 150, 250, and 350 μg/ml, and observed for 4 d (mifepristone used as positive control; replicated 3 times).19 At all extract concentrations, embryoid bodies were significantly smaller in diameter than the","page":5,"pdf":"SLR_HouttuyniaCordata_122025.pdf","row_type":"noael_study","study_id":"SLR_HouttuyniaCordata_122025_noael_002"} |
| CIR_vision_codex | NOAEL | =250 | mg/kg/d | rat | oral | Subchronic | repeated dose toxicity | {"citation":"5; 28; (6","dose":"Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5.","effect":"dominal muscle contraction, and fatigue, but no mortality or other significant changes. Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5. A 28-d toxicity study conducted in Sprague-Dawley rats (6/sex/group) treated with an ethanolic extract of Houttuynia cordata (250 - 1000 mg/kg/d) resulted in some mortality and several signs of liver and kidney toxicity in the higher dose groups.16 The no- observed-adverse-effect-level (NOAEL) was concluded to be 250 mg/kg/d. Another short-term toxicity study conducted in rabbits (strain not stated; 6/group) given an ethanolic extract of Houttuynia cordata (up to 1500 mg/kg bw/d) for 28 d reported no significant changes or signs of toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducte...","page":5,"pdf":"SLR_HouttuyniaCordata_122025.pdf","row_type":"noael_study","study_id":"SLR_HouttuyniaCordata_122025_noael_001"} |
| CIR_vision_codex | NOAEL | =350 | mg/kg/d | rat | - | 2-wk | developmental toxicity | {"citation":"17; 2; (6","dose":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/g...","effect":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/group) given the same doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%) resulted in several signs of kidney toxicity in the higher dose groups. The NOAEL was determined to be 350 mg/kg/d for female rats and 999 mg/kg/d for male rats. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES In Vitro Houttuynia Cordata Extract Embryoid bodies were generated from human-induced pluripotent stem cells (hiPSCs) and placed in aqueous Houttuynia cordata extract concentrations of 0, 150, 250, and 350 μg/ml, and observed for 4 d (mifepristone used as positive control; replicated 3 times).19 At all extract concentrations, embryoid bodies were significantly smaller in diameter than the","page":5,"pdf":"SLR_HouttuyniaCordata_122025.pdf","row_type":"noael_study","study_id":"SLR_HouttuyniaCordata_122025_noael_002"} |
UnifiedCodex:CIR:beta.noael_studies 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 350 | mg/kg/d | rat | - | 2-wk | developmental toxicity | SOURCE_SUBDIR=SLR_HouttuyniaCordata_122025; REPORT_TITLE=Safety Assessment of Houttuynia cordata-Derived Ingredients as Used in Cosmetics Status: Scientific Literature Review for Public Comment Release Date:; OPINION_NUMBER=SLR_HouttuyniaCordata_122025; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=December 2025; VALUE_TEXT=350; DOSE=toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/g...; EFFECT=toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/group) given the same doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%) resulted in several signs of kidney toxicity in the higher dose groups. The NOAEL was determined to be 350 mg/kg/d for female rats and 999 mg/kg/d for male rats. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES In Vitro Houttuynia Cordata Extract Embryoid bodies were generated from human-induced pluripotent stem cells (hiPSCs) and placed in aqueous Houttuynia cordata extract concentrations of 0, 150, 250, and 350 μg/ml, and observed for 4 d (mifepristone used as positive control; replicated 3 times).19 At all extract concentrations, embryoid bodies were significantly smaller in diameter than the; CITATION=17; 2; (6; CITATION_NUMBERS=[17,2,6]; REFERENCE=17; 2; (6; DETAILS_JSON={"cas_number":"164288-50-0","citation":"17; 2; (6","dose":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/g...","duration":"2-wk","effect":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/group) given the same doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%) resulted in several signs of kidney toxicity in the higher dose groups. The NOAEL was determined to be 350 mg/kg/d for female rats and 999 mg/kg/d for male rats. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES In Vitro Houttuynia Cordata Extract Embryoid bodies were generated from human-induced pluripotent stem cells (hiPSCs) and placed in aqueous Houttuynia cordata extract concentrations of 0, 150, 250, and 350 μg/ml, and observed for 4 d (mifepristone used as positive control; replicated 3 times).19 At all extract concentrations, embryoid bodies were significantly smaller in diameter than the","endpoint":"developmental toxicity","ingredient":"Houttuynia cordata-Derived Ingredients","loael_value":"","noael_unit":"mg/kg/d","noael_value":"350","page":5,"route":"","species":"rat","study_id":"SLR_HouttuyniaCordata_122025_noael_002"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 350 | mg/kg/d | rat | - | 2-wk | developmental toxicity | SOURCE_SUBDIR=SR939; REPORT_TITLE=Safety Assessment of Houttuynia cordata-Derived Ingredients as Used in Cosmetics Status: Scientific Literature Review for Public Comment Release Date:; OPINION_NUMBER=SR939; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=December 2025; VALUE_TEXT=350; DOSE=toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/g...; EFFECT=toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/group) given the same doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%) resulted in several signs of kidney toxicity in the higher dose groups. The NOAEL was determined to be 350 mg/kg/d for female rats and 999 mg/kg/d for male rats. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES In Vitro Houttuynia Cordata Extract Embryoid bodies were generated from human-induced pluripotent stem cells (hiPSCs) and placed in aqueous Houttuynia cordata extract concentrations of 0, 150, 250, and 350 μg/ml, and observed for 4 d (mifepristone used as positive control; replicated 3 times).19 At all extract concentrations, embryoid bodies were significantly smaller in diameter than the; CITATION=17; 2; (6; CITATION_NUMBERS=[17,2,6]; REFERENCE=17; 2; (6; DETAILS_JSON={"cas_number":"164288-50-0","citation":"17; 2; (6","dose":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/g...","duration":"2-wk","effect":"toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducted in F344/DuCrj rats (10/sex/group) given the same doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%) resulted in several signs of kidney toxicity in the higher dose groups. The NOAEL was determined to be 350 mg/kg/d for female rats and 999 mg/kg/d for male rats. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY STUDIES In Vitro Houttuynia Cordata Extract Embryoid bodies were generated from human-induced pluripotent stem cells (hiPSCs) and placed in aqueous Houttuynia cordata extract concentrations of 0, 150, 250, and 350 μg/ml, and observed for 4 d (mifepristone used as positive control; replicated 3 times).19 At all extract concentrations, embryoid bodies were significantly smaller in diameter than the","endpoint":"developmental toxicity","ingredient":"Houttuynia cordata-Derived Ingredients","loael_value":"","noael_unit":"mg/kg/d","noael_value":"350","page":5,"route":"","species":"rat","study_id":"SR939_noael_002"} |
| UnifiedCodex:CIR:beta.noael_studies | repeated dose toxicity | 250 | mg/kg/d | rat | oral | Subchronic | repeated dose toxicity | SOURCE_SUBDIR=SLR_HouttuyniaCordata_122025; REPORT_TITLE=Safety Assessment of Houttuynia cordata-Derived Ingredients as Used in Cosmetics Status: Scientific Literature Review for Public Comment Release Date:; OPINION_NUMBER=SLR_HouttuyniaCordata_122025; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=December 2025; VALUE_TEXT=250; DOSE=Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5.; EFFECT=dominal muscle contraction, and fatigue, but no mortality or other significant changes. Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5. A 28-d toxicity study conducted in Sprague-Dawley rats (6/sex/group) treated with an ethanolic extract of Houttuynia cordata (250 - 1000 mg/kg/d) resulted in some mortality and several signs of liver and kidney toxicity in the higher dose groups.16 The no- observed-adverse-effect-level (NOAEL) was concluded to be 250 mg/kg/d. Another short-term toxicity study conducted in rabbits (strain not stated; 6/group) given an ethanolic extract of Houttuynia cordata (up to 1500 mg/kg bw/d) for 28 d reported no significant changes or signs of toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducte...; CITATION=5; 28; (6; CITATION_NUMBERS=[5,28,6]; REFERENCE=5; 28; (6; DETAILS_JSON={"cas_number":"164288-50-0","citation":"5; 28; (6","dose":"Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5.","duration":"Subchronic","effect":"dominal muscle contraction, and fatigue, but no mortality or other significant changes. Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5. A 28-d toxicity study conducted in Sprague-Dawley rats (6/sex/group) treated with an ethanolic extract of Houttuynia cordata (250 - 1000 mg/kg/d) resulted in some mortality and several signs of liver and kidney toxicity in the higher dose groups.16 The no- observed-adverse-effect-level (NOAEL) was concluded to be 250 mg/kg/d. Another short-term toxicity study conducted in rabbits (strain not stated; 6/group) given an ethanolic extract of Houttuynia cordata (up to 1500 mg/kg bw/d) for 28 d reported no significant changes or signs of toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducte...","endpoint":"repeated dose toxicity","ingredient":"Houttuynia cordata-Derived Ingredients","loael_value":"","noael_unit":"mg/kg/d","noael_value":"250","page":5,"route":"oral","species":"rat","study_id":"SLR_HouttuyniaCordata_122025_noael_001"} |
| UnifiedCodex:CIR:beta.noael_studies | repeated dose toxicity | 250 | mg/kg/d | rat | oral | Subchronic | repeated dose toxicity | SOURCE_SUBDIR=SR939; REPORT_TITLE=Safety Assessment of Houttuynia cordata-Derived Ingredients as Used in Cosmetics Status: Scientific Literature Review for Public Comment Release Date:; OPINION_NUMBER=SR939; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=December 2025; VALUE_TEXT=250; DOSE=Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5.; EFFECT=dominal muscle contraction, and fatigue, but no mortality or other significant changes. Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5. A 28-d toxicity study conducted in Sprague-Dawley rats (6/sex/group) treated with an ethanolic extract of Houttuynia cordata (250 - 1000 mg/kg/d) resulted in some mortality and several signs of liver and kidney toxicity in the higher dose groups.16 The no- observed-adverse-effect-level (NOAEL) was concluded to be 250 mg/kg/d. Another short-term toxicity study conducted in rabbits (strain not stated; 6/group) given an ethanolic extract of Houttuynia cordata (up to 1500 mg/kg bw/d) for 28 d reported no significant changes or signs of toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducte...; CITATION=5; 28; (6; CITATION_NUMBERS=[5,28,6]; REFERENCE=5; 28; (6; DETAILS_JSON={"cas_number":"164288-50-0","citation":"5; 28; (6","dose":"Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5.","duration":"Subchronic","effect":"dominal muscle contraction, and fatigue, but no mortality or other significant changes. Short-Term and Subchronic Toxicity Studies Details regarding the repeated-dose oral toxicity studies summarized herein may be found in Table 5. A 28-d toxicity study conducted in Sprague-Dawley rats (6/sex/group) treated with an ethanolic extract of Houttuynia cordata (250 - 1000 mg/kg/d) resulted in some mortality and several signs of liver and kidney toxicity in the higher dose groups.16 The no- observed-adverse-effect-level (NOAEL) was concluded to be 250 mg/kg/d. Another short-term toxicity study conducted in rabbits (strain not stated; 6/group) given an ethanolic extract of Houttuynia cordata (up to 1500 mg/kg bw/d) for 28 d reported no significant changes or signs of toxicity in the test groups, when compared to the control.17 A 2-wk preliminary feeding study performed on F344/DuCrj rats (6/sex/group), testing doses of an ethanolic extract of Houttuynia cordata (0.5 - 5.0%), found no significant changes or mortality in any of the treated groups.18 A subsequent 13-wk feeding study conducte...","endpoint":"repeated dose toxicity","ingredient":"Houttuynia cordata-Derived Ingredients","loael_value":"","noael_unit":"mg/kg/d","noael_value":"250","page":5,"route":"oral","species":"rat","study_id":"SR939_noael_001"} |