INCI: HOUTTUYNIA CORDATA LEAF/STEM EXTRACT
Houttuynia Cordata Leaf/Stem Extract (CAS 164288-50-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning; antimicrobial. Reported NOAEL =250 mg/kg/d in rat (CIR_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
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Margin of Safety, dermal absorption, and sensitization profile summaries for Houttuynia Cordata Leaf/Stem Extract.
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8 study endpoints found for Houttuynia Cordata Leaf/Stem Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =250 mg/kg/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =250 mg/kg/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =250 mg/kg/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =250 mg/kg/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =350 mg/kg/d | - | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =350 mg/kg/d | - | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =350 mg/kg/d | - | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =350 mg/kg/d | - | rat | developmental toxicity | CIR_vision_codex |
Expert safety assessment and concern-level summary for Houttuynia Cordata Leaf/Stem Extract.
Public NOAEL study rows linked to Houttuynia Cordata Leaf/Stem Extract by CAS number or substance name.
Houttuynia Cordata Leaf/Stem Extract has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 8 toxicological study endpoint(s) are available in our database.
Houttuynia Cordata Leaf/Stem Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Houttuynia Cordata Leaf/Stem Extract functions as: Skin conditioning; antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 164288-50-0.
The NOAEL (No Observed Adverse Effect Level) for Houttuynia Cordata Leaf/Stem Extract is =250 mg/kg/d based on a repeated dose toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: CIR_vision_codex.
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