Is Hexyl Isobutyrate safe in cosmetics?
Hexyl Isobutyrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hexyl Isobutyrate
Also known as: Propanoic acid, 2-methyl-, hexyl ester, Isobutyric acid, hexyl ester, BRN 2075011, EINECS 219-075-8, FEMA No. 3172 (+8 more)
INCI: HEXYL ISOBUTYRATE
Hexyl Isobutyrate (CAS 2349-07-7) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2349-07-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
hexyl 2-methylpropanoate
InChIKey
CYHBDKTZDLSRMY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexyl Isobutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
189
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEXYL ISOBUTYRATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/267
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Hexyl Isobutyrate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Propanoic acid, 2-methyl-, hexyl ester
Isobutyric acid, hexyl ester
BRN 2075011
EINECS 219-075-8
FEMA No. 3172
Hexyl isobutanoate
n-Hexyl isobutanoate
n-Hexyl isobutyrate
1-Hexyl isobutyrate
Hexyl 2-methylpropanoate
Hexyl 2-methylpropionate
NSC 46108
UNII-5FC79GHU69
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187477
Frequently Asked Questions
Is Hexyl Isobutyrate allowed in the EU?
Hexyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexyl Isobutyrate do in cosmetics?
Hexyl Isobutyrate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2349-07-7.
Is Hexyl Isobutyrate used outside cosmetics?
Hexyl Isobutyrate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hexyl Isobutyrate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE
Good
Browse nearby
Perfuming
HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE-8-METHANOL
Good
Browse nearby
Perfuming
HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE-8-METHYL ACETATE
Good
Browse nearby
Perfuming
Is Hexyl Isobutyrate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hexyl Isobutyrate in your formulation.