Is Hexyl Hexanoate safe in cosmetics?
Hexyl Hexanoate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hexyl Hexanoate
Also known as: Hexanoic acid, hexyl ester, BRN 1762037, EINECS 228-952-4, FEMA No. 2572, Hexyl caproate (+4 more)
INCI: HEXYL HEXANOATE
Hexyl Hexanoate (CAS 6378-65-0) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 6378-65-0 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
hexyl hexanoate
InChIKey
NCDCLPBOMHPFCV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexyl Hexanoate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 675 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
164
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEXYL CAPROATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEXYL HEXANOATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Hexyl Hexanoate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Hexanoic acid, hexyl ester
BRN 1762037
EINECS 228-952-4
FEMA No. 2572
Hexyl caproate
n-Hexyl hexanoate
Hexyl hexoate
NSC 53799
UNII-GI6FE1QMW6
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187323
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
HEXYL HEXANOATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Hexyl Hexanoate allowed in the EU?
Hexyl Hexanoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexyl Hexanoate do in cosmetics?
Hexyl Hexanoate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 6378-65-0.
Is Hexyl Hexanoate used outside cosmetics?
Hexyl Hexanoate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hexyl Hexanoate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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