Is Hexyl Butyrate safe in cosmetics?
Hexyl Butyrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hexyl Butyrate
Also known as: BRN 1754469, EINECS 220-136-6, FEMA No. 2568, 1-Hexyl butyrate, UNII-74HY6P24G7 (+7 more)
INCI: HEXYL BUTYRATE
Hexyl Butyrate (CAS 2639-63-6) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient (fruity top note modifier). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2639-63-6 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient (fruity top note modifier)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
hexyl butanoate
InChIKey
XAPCMTMQBXLDBB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS (No. 2568); no cosmetic restriction under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexyl Butyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 8100 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
153
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEXYL BUTYRATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Hexyl Butyrate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
BRN 1754469
EINECS 220-136-6
FEMA No. 2568
1-Hexyl butyrate
UNII-74HY6P24G7
Butanoic acid, hexyl ester
Butyric acid, hexyl ester
Hexyl butanoate
N-Hexyl N-butanoate
N-Hexyl N-butyrate
N-Hexyl butanoate
N-Hexyl butyrate
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
artificial_saliva; detected; emissions; Europe; Toys and children's products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182794
Frequently Asked Questions
Is Hexyl Butyrate allowed in the EU?
Hexyl Butyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexyl Butyrate do in cosmetics?
Hexyl Butyrate functions as: Fragrance ingredient (fruity top note modifier). It is classified as a cosmetic ingredient in our database. CAS number: 2639-63-6.
Is Hexyl Butyrate used outside cosmetics?
Hexyl Butyrate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hexyl Butyrate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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