Is Hexapeptide-10 safe in cosmetics?
Hexapeptide-10 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Active Ingredient
Hexapeptide-10
INCI: HEXAPEPTIDE-10
Hexapeptide-10 (CAS 146439-94-3) is a cosmetic active ingredient functioning as Humectant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 146439-94-3 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S,3S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-methylpentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
InChIKey
OFGVZFQUFJYSGS-CPDXTSBQSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-10.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "barrier-repair, anti-wrinkle", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J …
Expert Verdict
Expert safety assessment and concern-level summary for Hexapeptide-10.
Frequently Asked Questions
Is Hexapeptide-10 allowed in the EU?
Hexapeptide-10 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-10 do in cosmetics?
Hexapeptide-10 functions as: Humectant. It is classified as a Active Ingredient in our database. CAS number: 146439-94-3.
Compliance Tools
Check Hexapeptide-10 compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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