Is Hexadienal Diethyl Acetal safe in cosmetics?
Hexadienal Diethyl Acetal has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Hexadienal Diethyl Acetal
INCI: 2,4-HEXADIENAL DIETHYL ACETAL
Hexadienal Diethyl Acetal (CAS 67746-30-9) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 67746-30-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Hexadienal Diethyl Acetal is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H315, H317, H319).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(E)-1,1-diethoxyhex-2-ene
InChIKey
WMQKYHTZGYIHHD-CMDGGOBGSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexadienal Diethyl Acetal.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
2700 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [461] Epstein WL (1977): Report to RIFM, 21 March, unpublished.
HRIPT Human Patch Test Studies
4 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
| HMT | - | 0 | 5400 | - | - |
| HMT | - | 0 | 5400 | - | - |
| HMT | - | 0 | 5400 | - | - |
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 438
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1383
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
(E)-2-HEXENAL DIETHYL ACETAL | 2023 | No safety concern at current levels of intake when used as a flavouring agent | Considered for specifications only | TRS 1050-JECFA 96/46 | FAS 54-JECFA 63/317
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
LEAFALDEHYDE DIETHYL ACETAL | 2023 | No safety concern at current levels of intake when used as a flavouring agent | Considered for specifications only | TRS 1050-JECFA 96/46 | FAS 54-JECFA 63/317
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
EU Banned in Cosmetics
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Hexadienal Diethyl Acetal.
Regulatory Flags
fragrance-component
eu_banned_cosmetics
fda_food_additive
eu_cosing_listed
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
banned; Europe; Personal care
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hexadienal Diethyl Acetal allowed in the EU?
Hexadienal Diethyl Acetal EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexadienal Diethyl Acetal do in cosmetics?
Hexadienal Diethyl Acetal functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 67746-30-9.
Is Hexadienal Diethyl Acetal used outside cosmetics?
Hexadienal Diethyl Acetal also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Hexadienal Diethyl Acetal have different safety status in cosmetics vs industrial chemicals?
Hexadienal Diethyl Acetal is prohibited in EU cosmetics but has active industrial GHS classifications (H226, H302, H315, H317, H319).
Compliance Tools
Check Hexadienal Diethyl Acetal compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
Poly(Linseed Oil)
Good
Chemical family
Binding, film forming, hair condition...
HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE
Good
Browse nearby
Perfuming
HEXAHYDRO-TETRAMETHYL-METHANONAPHTHALENE-8-METHANOL
Good
Browse nearby
Perfuming
Is Hexadienal Diethyl Acetal in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Hexadienal Diethyl Acetal in your formulation.