Is Hexadec-7-en-16-olide safe in cosmetics?
Hexadec-7-en-16-olide has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hexadec-7-en-16-olide
Also known as: (Z)-Oxacycloheptadec-8-en-2-one
INCI: HEXADEC-7-EN-16-OLIDE
Hexadec-7-en-16-olide (CAS 123-69-3) is a cosmetic cosmetic ingredient functioning as Fragrance (masking). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 123-69-3 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (masking)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(8Z)-1-oxacycloheptadec-8-en-2-one
InChIKey
NVIPUOMWGQAOIT-RQOWECAXSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not restricted under 21 CFR; FEMA GRAS for flavor use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexadec-7-en-16-olide.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
AMBRETTOLIDE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Hexadec-7-en-16-olide.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
Known Synonyms
(Z)-Oxacycloheptadec-8-en-2-one
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
consumer_product
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3727440
Frequently Asked Questions
Is Hexadec-7-en-16-olide allowed in the EU?
Hexadec-7-en-16-olide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexadec-7-en-16-olide do in cosmetics?
Hexadec-7-en-16-olide functions as: Fragrance (masking). It is classified as a cosmetic ingredient in our database. CAS number: 123-69-3.
Is Hexadec-7-en-16-olide used outside cosmetics?
Hexadec-7-en-16-olide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hexadec-7-en-16-olide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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