Is HC Yellow No. 7 safe in cosmetics?
HC Yellow No. 7 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 8 toxicological study endpoint(s) are available in our database.
HC Yellow No. 7
INCI: HC YELLOW NO. 7
HC Yellow No. 7 (CAS 104226-21-3) is a cosmetic cosmetic ingredient functioning as Hair Dyeing (non-oxidative semi-permanent). Reported NOAEL =25 mg/kg bw/day (SCCNFP_vision_codex); EU Regulation 1223/2009 status: prohibited, max 0.25%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 104226-21-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HC Yellow No. 7 is prohibited in EU cosmetics at max 0.25% but has active industrial GHS classifications (H301, H302, H335, H400, H410).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Dyeing (non-oxidative semi-permanent)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[4-[(4-aminophenyl)diazenyl]-N-(2-hydroxyethyl)-3-methylanilino]ethanol
InChIKey
YSVKKVUAUKQDBY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
0.25%
US US Status
permitted
US Notes
Permitted under coal-tar hair dye exemption (FD&C Act §601(a))
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Yellow No. 7.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for HC Yellow No. 7. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =25 mg/kg bw/day | oral | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =25 mg/kg bw/day | oral | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =25 mg/kg bw/day | oral | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =25 mg/kg bw/day | oral | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =80 mg/kg bw/day | oral | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =80 mg/kg bw/day | oral | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =80 mg/kg bw/day | oral | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =80 mg/kg bw/day | oral | - | repeated dose toxicity | SCCNFP_vision_codex |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in oxidative hair dye products. Max: 0,25%.
BRIN Brazil/India Cosmetics
India: Restricted · max 0,25%
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "104226-21-3", "ingredient_class": "direct_dye", "chemical_class": "nitro", "molecular_weight_Da": "243.26", "color_result_on_hair": "Yellow-gold", "shade_range": "blonde", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "moderat…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Yellow No. 7.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Yellow No. 7 by CAS number or substance name.
Studies
8
Lowest NOAEL
25 mg/kg bw/day
Highest NOAEL
80 mg/kg bw/day
SCCNFP_vision_codex
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is HC Yellow No. 7 allowed in the EU?
HC Yellow No. 7 EU regulatory status: prohibited. Maximum allowed concentration: 0.25%. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Yellow No. 7 do in cosmetics?
HC Yellow No. 7 functions as: Hair Dyeing (non-oxidative semi-permanent). It is classified as a cosmetic ingredient in our database. CAS number: 104226-21-3.
What is the NOAEL for HC Yellow No. 7?
The NOAEL (No Observed Adverse Effect Level) for HC Yellow No. 7 is =25 mg/kg bw/day based on a repeated dose toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: SCCNFP_vision_codex.
Is HC Yellow No. 7 used outside cosmetics?
HC Yellow No. 7 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HC Yellow No. 7 have different safety status in cosmetics vs industrial chemicals?
HC Yellow No. 7 is prohibited in EU cosmetics at max 0.25% but has active industrial GHS classifications (H301, H302, H335, H400, H410).
Compliance Tools
Check HC Yellow No. 7 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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