Is HC Orange No. 3 safe in cosmetics?
HC Orange No. 3 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 8 toxicological study endpoint(s) are available in our database.
HC Orange No. 3
INCI: HC ORANGE NO. 3
HC Orange No. 3 (CAS 81612-54-6) is a cosmetic cosmetic ingredient functioning as Hair dyeing — semi-permanent direct dye (orange). Reported NOAEL =100 mg/kg bw/day in rat (SCCNFP_vision_codex); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 81612-54-6 →
Auto-generated CPSR Part A draft with source citations
Function
Hair dyeing — semi-permanent direct dye (orange)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-[4-(2-hydroxyethylamino)-3-nitrophenoxy]propane-1,2-diol
InChIKey
SZWQTBKBBNGUAB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted under coal-tar hair dye exemption (FD&C Act §601(a))
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Orange No. 3.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for HC Orange No. 3. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | - | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | - | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | - | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =100 mg/kg bw/day | - | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =300 mg/kg bw/day | - | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =300 mg/kg bw/day | - | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =300 mg/kg bw/day | - | rat | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =300 mg/kg bw/day | - | rat | repeated dose toxicity | SCCNFP_vision_codex |
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1237
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1237
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Orange No. 3.
Regulatory Flags
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Orange No. 3 by CAS number or substance name.
Studies
8
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
SCCNFP_vision_codex
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
Frequently Asked Questions
Is HC Orange No. 3 allowed in the EU?
HC Orange No. 3 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Orange No. 3 do in cosmetics?
HC Orange No. 3 functions as: Hair dyeing — semi-permanent direct dye (orange). It is classified as a cosmetic ingredient in our database. CAS number: 81612-54-6.
What is the NOAEL for HC Orange No. 3?
The NOAEL (No Observed Adverse Effect Level) for HC Orange No. 3 is =100 mg/kg bw/day based on a repeated dose toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: SCCNFP_vision_codex.
Compliance Tools
Check HC Orange No. 3 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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