Is HC Orange No. 2 safe in cosmetics?
HC Orange No. 2 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
HC Orange No. 2
Also known as: UNII-86WS98470U, 2-(4-((2-Aminoethyl)amino)-3-nitrophenoxy)ethanol, Ethanol, 2-(4-((2-aminoethyl)amino)-3-nitrophenoxy)-, HC Orange 2, Imexine FAB
INCI: HC ORANGE NO. 2
HC Orange No. 2 (CAS 85765-48-6) is a cosmetic cosmetic ingredient functioning as Hair dyeing — semi-permanent direct dye (orange). Reported NOAEL =0.016 mg/kg in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 85765-48-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HC Orange No. 2 is classified GHS Danger (H317, H318) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing — semi-permanent direct dye (orange)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[4-(2-aminoethylamino)-3-nitrophenoxy]ethanol
InChIKey
WXGKXLXGYOYZMX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted under coal-tar hair dye exemption (FD&C Act §601(a))
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Orange No. 2.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Orange No. 2. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.016 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.016 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.016 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.016 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =20 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =20 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =20 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =20 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =20 mg/kg/day | - | - | NOAEL study | SCCS_vision_codex |
| NOAEL | =20 mg/kg bw | oral | rat | dermal absorption | SCCS_vision_codex |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0.01.
BRIN Brazil/India Cosmetics
India: Restricted · max 0.01
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.055% | - | - | SCCP/0116 |
| measured | 98.4% | - | - | SCCP/0116 |
| measured | 98.6% | - | - | SCCP/0116 |
| measured | 98.5% | - | - | SCCP/0116 |
| measured | 1.38% | - | - | SCCP/0116 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "85765-48-6", "ingredient_class": "direct_dye", "chemical_class": "nitro", "molecular_weight_Da": "212.20", "color_result_on_hair": "Orange", "shade_range": "red", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "moderate", "heat…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Orange No. 2.
Regulatory Flags
eu_children_restricted
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Orange No. 2 by CAS number or substance name.
Studies
36
Lowest NOAEL
0.016
Highest NOAEL
500
Units vary across source rows: mg/kg/day, mg/kg, mg/kg bw
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.055% | - | - |
| 98.4% | - | - |
| 98.6% | - | - |
| 98.5% | - | - |
| 1.38% | - | - |
Known Synonyms
UNII-86WS98470U
2-(4-((2-Aminoethyl)amino)-3-nitrophenoxy)ethanol
Ethanol, 2-(4-((2-aminoethyl)amino)-3-nitrophenoxy)-
HC Orange 2
Imexine FAB
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Canada; Personal care; Substances in PCP - Canada (4/2014)
children; Europe; Personal care
children; Europe; Personal care
Frequently Asked Questions
Is HC Orange No. 2 allowed in the EU?
HC Orange No. 2 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Orange No. 2 do in cosmetics?
HC Orange No. 2 functions as: Hair dyeing — semi-permanent direct dye (orange). It is classified as a cosmetic ingredient in our database. CAS number: 85765-48-6.
What is the NOAEL for HC Orange No. 2?
The NOAEL (No Observed Adverse Effect Level) for HC Orange No. 2 is =0.016 mg/kg based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is HC Orange No. 2 used outside cosmetics?
HC Orange No. 2 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HC Orange No. 2 have different safety status in cosmetics vs industrial chemicals?
HC Orange No. 2 is classified GHS Danger (H317, H318) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check HC Orange No. 2 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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