Is HC Blue No. 17 safe in cosmetics?
HC Blue No. 17 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
HC Blue No. 17
Also known as: UNII-8432OLU48W, 1-Propanaminium, 3-((4-amino-9,10-dihydro-3-methyl-9,10-dioxo-1-anthracenyl)amino)-N,N,N-trimethyl-, methyl sulfate (1:1), Ammonium, (3-((4-amino-3-methyl-1-anthraquinonyl)amino)propyl)trimethyl-, methyl sulfate, Cationic Blue 0347 liquid
INCI: HC BLUE NO. 17
HC Blue No. 17 (CAS 16517-75-2) is a cosmetic cosmetic ingredient functioning as Hair dyeing — anthraquinone-based semi-permanent direct dye. Reported NOAEL =0.04 mg/kg bw/d in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 16517-75-2 →
Auto-generated CPSR Part A draft with source citations
Function
Hair dyeing — anthraquinone-based semi-permanent direct dye
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-[(4-amino-3-methyl-9,10-dioxoanthracen-1-yl)amino]propyl-trimethylazanium;methyl sulfate
InChIKey
DXNBFDTUGLSSOR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted under coal tar hair dye exemption (21 CFR 740.2). No specific FDA restriction.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Blue No. 17.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Blue No. 17. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.04 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.04 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.04 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.04 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.05 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.05 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.05 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.05 mg/kg bw/d | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =40 mg/kg bw/d | oral | rabbit | genotoxicity | SCCS_vision_codex |
| NOAEL | =40 mg/kg bw/d | oral | rabbit | genotoxicity | SCCS_vision_codex |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products. Max: (b) 2,0%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 2,0%
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (2 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 1.056% | - | - | SCCS/0128 |
| measured | 0.834% | - | - | SCCS/0128 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "16517-75-2", "ingredient_class": "direct_dye", "chemical_class": "anthraquinone", "molecular_weight_Da": "356.37", "color_result_on_hair": "Blue", "shade_range": "fashion_color", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Blue No. 17.
Regulatory Flags
potential-allergen
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Blue No. 17 by CAS number or substance name.
Studies
28
Lowest NOAEL
0.04
Highest NOAEL
1000
Units vary across source rows: mg/kg bw/d, mg/kg/day
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 1.056% | - | - |
| 0.834% | - | - |
Known Synonyms
UNII-8432OLU48W
1-Propanaminium, 3-((4-amino-9,10-dihydro-3-methyl-9,10-dioxo-1-anthracenyl)amino)-N,N,N-trimethyl-, methyl sulfate (1:1)
Ammonium, (3-((4-amino-3-methyl-1-anthraquinonyl)amino)propyl)trimethyl-, methyl sulfate
Cationic Blue 0347 liquid
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is HC Blue No. 17 allowed in the EU?
HC Blue No. 17 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Blue No. 17 do in cosmetics?
HC Blue No. 17 functions as: Hair dyeing — anthraquinone-based semi-permanent direct dye. It is classified as a cosmetic ingredient in our database. CAS number: 16517-75-2.
What is the NOAEL for HC Blue No. 17?
The NOAEL (No Observed Adverse Effect Level) for HC Blue No. 17 is =0.04 mg/kg bw/d based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Compliance Tools
Check HC Blue No. 17 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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