Is Harpagide safe in cosmetics?
Harpagide has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Harpagide
INCI: HARPAGIDE
Harpagide (CAS 6926-08-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning (iridoid glycoside from Harpagophytum procumbens — Devil's. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 6926-08-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (iridoid glycoside from Harpagophytum procumbens — Devil's Claw)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(1S,4aS,5R,7S,7aR)-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-4a,5,7-triol
InChIKey
XUWSHXDEJOOIND-YYDKPPGPSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR prohibition; not an FDA-restricted cosmetic ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Harpagide.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Harpagide.
Chemical Function
Humectant
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL464889
Frequently Asked Questions
Is Harpagide allowed in the EU?
Harpagide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Harpagide do in cosmetics?
Harpagide functions as: Skin conditioning (iridoid glycoside from Harpagophytum procumbens — Devil's Claw). It is classified as a cosmetic ingredient in our database. CAS number: 6926-08-5.
Is Harpagide used outside cosmetics?
Harpagide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Harpagide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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