Is Guar Hydroxypropyltrimonium Chloride safe in cosmetics?
Guar Hydroxypropyltrimonium Chloride has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Guar Hydroxypropyltrimonium Chloride
Also known as: UNII-B16G315W7A
INCI: GUAR HYDROXYPROPYLTRIMONIUM CHLORIDE
Guar Hydroxypropyltrimonium Chloride (CAS 65497-29-2) is a cosmetic cosmetic ingredient functioning as conditioning agent, anti-static, film-forming, viscosity modifier. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 65497-29-2 →
Auto-generated CPSR Part A draft with source citations
Function
conditioning agent, anti-static, film-forming, viscosity modifier
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Panel assessed galactomannans including guar hydroxypropyltrimonium chloride; concluded safe as used. Substantial molecular size makes skin penetration unlikely.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Guar Hydroxypropyltrimonium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Guar Hydroxypropyltrimonium Chloride, relevant to systemic exposure and MoS calculations.
Absorption %
0%
Penetration Level
surface
Penetration Depth
surface only
Molecular Weight
Variable Da
Log P
n/a
Systemic Absorption
no
Topical Bioavailability
0%
Safety Margin Factor
none
Source: CIR
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Shampoo | 0.1–0.5 | 1 | CIR/VCRP |
| Conditioner | 0.1–0.5 | 1 | CIR/VCRP |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
biopolymer
{"cas_number": "65497-29-2", "polymer_class": "seed_gum", "botanical_source": "Cyamopsis tetragonoloba (cationized)", "molecular_weight_range_kDa": "300-1200", "monosaccharide_composition": "mannose/galactose/quaternary ammonium", "degree_of_branching": "moderately_branched", "charge_type": "cationic", "viscosity_1pct_solution_mPas": "1500-3500", "pseudoplastic_behavior": "moderate", "thixotropy":…
concentration
{"min_concentration_pct": "0.2", "max_concentration_pct": "1.5", "typical_concentration_pct": "0.8", "product_type": "Hair Conditioner", "function_at_concentration": "Natural conditioning", "source": "CIR Safety Assessment"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "20", "estimated_cost_per_kg_usd_high": "38", "natural_premium_markup_pct": "25", "organic_certified_premium_pct": "50", "supply_chain_volatility": "medium", "primary_source_region": "India/US", "synthetic_vs_natural_cost_ratio": "1.8", "bulk_discount_threshold_kg": "100", "seasonal_price_variation": "medium", "commodity_or_specialty": "s…
dermal_absorption
{"molecular_weight_da": "Variable", "skin_penetration_level": "surface", "penetration_depth": "surface only", "absorption_pct": "0", "systemic_absorption": "no", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "no", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0", "source": "CIR"}
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "28-60", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low aquatic toxicity", "freshwater_toxicity": "minimal impact", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "pa…
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "emulsifier_type": "o_w", "emulsion_stabilization_mechanism": "electrostatic_steric", "co_emulsifier_pairs": "none_required", "optimal_oil_phase_pct": "5-20", "optimal_water_phase_pct": "80-95", "electrolyte_tolerance": "high", "pH_emulsion_stability_range": "3.0-9.5", "viscosity_building_contribution": "high", "droplet_size_range_um": "0.3-12", "zeta_potential…
hair_care
{"hair_function": "conditioning", "hair_type_suitability": "fine/medium", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral…
hair_conditioning
{"cas_number": "65497-29-2", "ingredient_class": "cationic_conditioner", "chemical_type": "cationic_guar", "charge_density_meq_g": "0.5-0.8", "substantivity_to_hair": "excellent", "deposition_from_shampoo": "yes", "deposition_from_conditioner": "yes", "conditioning_mechanism": "electrostatic", "hair_penetration": "cuticle", "molecular_weight_effect_on_penetration": "high_MW_polysaccharide", "wet_c…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-adhesive/cohesive
Anti-static agent
Film former
Softener and conditioner
Thickening agent
Viscosity modifier
Regulatory List Membership (1)
EU Regulated in Personal Care
Expert Verdict
Expert safety assessment and concern-level summary for Guar Hydroxypropyltrimonium Chloride.
Regulatory Flags
cir-approved
conditioning-polymer
natural
plant-derived
galactomannan
coacervation
cosmos-eligible
biodegradable
anti-static
buildup-risk-fine-hair
streaming-potential-confirmed
electrokinetic-data
Known Synonyms
UNII-B16G315W7A
Chemical Function
Film former
Anti-static agent
Softener and conditioner
Viscosity modifier
Regulatory Lists
Europe; Personal care - hair styling and care - shampoo-dandruff
Europe; Personal care - hair styling and care - shampoo-dandruff
Europe; Personal care
Europe; Personal care
Europe; Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Guar Hydroxypropyltrimonium Chloride allowed in the EU?
Guar Hydroxypropyltrimonium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guar Hydroxypropyltrimonium Chloride do in cosmetics?
Guar Hydroxypropyltrimonium Chloride functions as: conditioning agent, anti-static, film-forming, viscosity modifier. It is classified as a cosmetic ingredient in our database. CAS number: 65497-29-2.
Compliance Tools
Check Guar Hydroxypropyltrimonium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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