Is Guaiazulene safe in cosmetics?
Guaiazulene has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Fragrance
Guaiazulene
Also known as: Azulene, 1,4-dimethyl-7-(1-methylethyl)-, 1,4-Dimethyl-7-(1-methylethyl)Azulene, 1,4-Dimethyl-7-isopropylazulene, 3,8-Dimethyl-5-(2-propyl)azulene, AZULENE, 1,4-DIMETHYL-7-ISOPROPYL- (+14 more)
INCI: GUAIAZULENE
Guaiazulene (CAS 489-84-9) is a cosmetic fragrance functioning as Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 489-84-9 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Use only in externally applied cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Guaiazulene.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
acne
{"cas_number": "489-84-9", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "2", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "5-15", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Dye
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Guaiazulene.
Regulatory Flags
ifra_fragrance
Known Synonyms
Azulene, 1,4-dimethyl-7-(1-methylethyl)-
1,4-Dimethyl-7-(1-methylethyl)Azulene
1,4-Dimethyl-7-isopropylazulene
3,8-Dimethyl-5-(2-propyl)azulene
AZULENE, 1,4-DIMETHYL-7-ISOPROPYL-
Azulene, 7-isopropyl-1,4-dimethyl-
Azulene,1,4-dimethyl-7-(1-methylethyl)-
1, 4-Dimethyl-7-isopropylazulene
1,4-Dimethyl-7-(1-methyl)-azulene (azulon)
1,4-Dimethyl-7-(1-methylethyl)-Azulene
1,4-Dimethyl-7-(1-methylethyl)azulene, 9CI
1,4-Dimethyl-7-(propan-2-yl)azulene
1,4-Dimethyl-7-isopropylazulene (JAN)
7-Isopropyl- 1,4-dimethylazulene
7-Isopropyl-1,4-dimethyl-Azulene
4-05-00-01751
BRN 1365001
EINECS 207-701-2
UNII-2OZ1K9JKQC
Chemical Function
Biocide
Fragrance
Dye
Regulatory Lists
IFRA Transparency
Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GUAIAZULEN
ChEMBL ID
CHEMBL1408759
Max Phase
-1
Adverse Event Associations
36
Frequently Asked Questions
Is Guaiazulene allowed in the EU?
Guaiazulene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guaiazulene do in cosmetics?
Guaiazulene functions as: Antioxidant. It is classified as a Fragrance in our database. CAS number: 489-84-9.
Is Guaiazulene used outside cosmetics?
Guaiazulene also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Guaiazulene compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Dihydromyrcenol
Excellent
Same category
Fragrance; aroma chemical; fresh/clea...
Hedione
Excellent
Same category
Perfuming, Fragrance Diffuser, Volume...
Iso E Super
Excellent
Same category
Fragrance; aroma chemical; woody/ambe...
Alpha-Isomethyl Ionone
Good
Same category
Fragrance ingredient
Anise Alcohol
Good
Same category
Fragrance ingredient
Anisic Acid
Good
Same category
Fragrance, Antimicrobial Preservation...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
Guaiazulene
Good
Chemical family
Skin conditioning, soothing (anti-inf...
OCTAHYDRO-3,8-DIMETHYLAZULEN-5-YLPROPAN-2-OL
Good
Chemical family
Perfuming
Gadi Iecur
Moderate
Browse nearby
Fragrance
Is Guaiazulene in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Guaiazulene in your formulation.