Is Glycyrrhetinic Acid safe in cosmetics?
Glycyrrhetinic Acid has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Glycyrrhetinic Acid
Also known as: Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta.,20.beta.)-, Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)-, Enoxolone, Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-, 8beta-Glycyrrhetinic acid (+15 more)
INCI: GLYCYRRHETINIC ACID
Glycyrrhetinic Acid (CAS 471-53-4) is a cosmetic cosmetic ingredient functioning as Skin conditioning — anti-inflammatory, soothing agent derived from licorice. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 471-53-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning — anti-inflammatory, soothing agent derived from licorice
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no CFR restriction; CIR concluded safe in present practices of use and concentration
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glycyrrhetinic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Glycyrrhetinic Acid.
Known Synonyms
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta.,20.beta.)-
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)-
Enoxolone
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-
8beta-Glycyrrhetinic acid
4-10-00-03775
BRN 2229654
EINECS 207-444-6
18-beta-Glycyrrhetic acid
18-beta-Glycyrrhetinic acid
3-beta-Hydroxy-11-oxoolean-12-en-30-oic acid
Enoxolonum
UNII-P540XA09DR
(2S,4aS,6aS,6bR,10S,12aS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
18b-Glycyrrhetic acid
18b-Glycyrrhetinic acid
18b-Glycyrrhtinic acid
18beta-glycyrrhetic acid
3-Glycyrrhetinic acid
3-Hydroxy-11-oxoolean-12-en-29-oate
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ENOXOLONE
ChEMBL ID
CHEMBL230006
Max Phase
2
Frequently Asked Questions
Is Glycyrrhetinic Acid allowed in the EU?
Glycyrrhetinic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glycyrrhetinic Acid do in cosmetics?
Glycyrrhetinic Acid functions as: Skin conditioning — anti-inflammatory, soothing agent derived from licorice. It is classified as a cosmetic ingredient in our database. CAS number: 471-53-4.
Is Glycyrrhetinic Acid used outside cosmetics?
Glycyrrhetinic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Glycyrrhetinic Acid compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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