Is Glycolide safe in cosmetics?
Glycolide has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Glycolide
Also known as: EINECS 207-954-9, Glycollide, NSC 403079, UNII-YRZ676PGU6
INCI: GLYCOLIDE
Glycolide (CAS 502-97-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent; cyclic diester precursor of glycolic acid. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 502-97-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent; cyclic diester precursor of glycolic acid
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1,4-dioxane-2,5-dione
InChIKey
RKDVKSZUMVYZHH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no 21 CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glycolide.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Glycolide.
Known Synonyms
EINECS 207-954-9
Glycollide
NSC 403079
UNII-YRZ676PGU6
Chemical Function
Humectant
Softener and conditioner
Frequently Asked Questions
Is Glycolide allowed in the EU?
Glycolide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glycolide do in cosmetics?
Glycolide functions as: Skin conditioning agent; cyclic diester precursor of glycolic acid. It is classified as a cosmetic ingredient in our database. CAS number: 502-97-6.
Is Glycolide used outside cosmetics?
Glycolide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Glycolide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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