Is Glycerophosphocholine safe in cosmetics?
Glycerophosphocholine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Glycerophosphocholine
Also known as: Choline hydroxide, (R)-2,3-dihydroxypropyl hydrogen phosphate, inner salt, Choline, hydroxide, 2,3-dihydroxypropyl hydrogen phosphate, inner salt, D-, Ethanaminium, 2-(((2,3-dihydroxypropoxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt, (R)-, Choline alfoscerate, Choline-alfoscerate (+2 more)
INCI: GLYCEROPHOSPHOCHOLINE
Glycerophosphocholine (CAS 28319-77-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 28319-77-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(2R)-2,3-dihydroxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
InChIKey
SUHOQUVVVLNYQR-MRVPVSSYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction; not prohibited under 21 CFR 700
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glycerophosphocholine.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Glycerophosphocholine.
Known Synonyms
Choline hydroxide, (R)-2,3-dihydroxypropyl hydrogen phosphate, inner salt
Choline, hydroxide, 2,3-dihydroxypropyl hydrogen phosphate, inner salt, D-
Ethanaminium, 2-(((2,3-dihydroxypropoxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, hydroxide, inner salt, (R)-
Choline alfoscerate
Choline-alfoscerate
Alpha-GPC
L-α-Glycerylphosphorylcholine
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1567463
Adverse Event Associations
35
Frequently Asked Questions
Is Glycerophosphocholine allowed in the EU?
Glycerophosphocholine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glycerophosphocholine do in cosmetics?
Glycerophosphocholine functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 28319-77-9.
Is Glycerophosphocholine used outside cosmetics?
Glycerophosphocholine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Glycerophosphocholine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
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