Is Glucuronolactone safe in cosmetics?
Glucuronolactone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Glucuronolactone
Also known as: D-Glucuronic acid, gamma-lactone, D-Glucuronic acid, .gamma.-lactone, D-Glucuronolactone, D-(+)-Glucuronic acid γ-lactone, 5-18-05-00033 (+14 more)
INCI: GLUCURONOLACTONE
Glucuronolactone (CAS 32449-92-6) is a cosmetic cosmetic ingredient functioning as Humectant, skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 32449-92-6 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2R)-2-[(2S,3R,4S)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde
InChIKey
UYUXSRADSPPKRZ-SKNVOMKLSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — GRAS as dietary supplement; not restricted in cosmetics under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glucuronolactone.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Glucuronolactone.
Known Synonyms
D-Glucuronic acid, gamma-lactone
D-Glucuronic acid, .gamma.-lactone
D-Glucuronolactone
D-(+)-Glucuronic acid γ-lactone
5-18-05-00033
BRN 0083595
Dicurone
EINECS 251-053-3
D-Glucofuranuronic acid, gamma-lactone
Glucoxy
Glucuron
Glucurone
Glucuronic acid lactone
D-Glucuronic acid lactone
D-Glucurono-3,6-lactone
D-Glucurono-6,3-lactone
Glucurono-6,3-lactone
Glucuronosan
Gluronsan
Chemical Function
Softener and conditioner
Humectant
Regulatory Lists
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
glucurolactone
ChEMBL ID
CHEMBL2107425
Adverse Event Associations
3
Frequently Asked Questions
Is Glucuronolactone allowed in the EU?
Glucuronolactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glucuronolactone do in cosmetics?
Glucuronolactone functions as: Humectant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 32449-92-6.
Is Glucuronolactone used outside cosmetics?
Glucuronolactone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Glucuronolactone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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