What is the NOAEL for Glucurolactone?
Glucurolactone has 7 NOAEL studies in the database. The lowest reported value is XE4Y3016M9 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Glucurolactone
Also known as: D-Glucuronic acid, gamma-lactone, D-Glucuronic acid, .gamma.-lactone, D-Glucuronolactone, D-(+)-Glucuronic acid γ-lactone, 5-18-05-00033 (+15 more)
CAS 32449-92-6
Glucurolactone (CAS 32449-92-6) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Glucurolactone
CAS Number
32449-92-6
DTXSID
DTXSID6041844
Molecular Formula
C6H8O6
InChI Key
OGLCQHRZUSEXNB-WHDMSYDLSA-N
Monoisotopic Mass
176.032088
Synonyms
D-Glucuronic acid, gamma-lactoneD-Glucuronic acid, .gamma.-lactoneD-GlucuronolactoneD-(+)-Glucuronic acid γ-lactone5-18-05-00033BRN 0083595DicuroneEINECS 251-053-3D-Glucofuranuronic acid, gamma-lactoneGlucoxyGlucuronGlucurone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
Softener and conditionerHumectant
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| XE4Y3016M9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XE4Y3016M9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XE4Y3016M9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| XE4Y3016M9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =1000 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =1000 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Glucurolactone | 251-053-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
glucurolactone
ChEMBL Phase
Not listed
Adverse Events
3
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Glucurolactone?
Glucurolactone appears on 1 regulatory/inventory list including pharmaceutical. Source: EPA CPDat.
Is Glucurolactone used in cosmetics?
Yes, Glucurolactone is also indexed as a cosmetic ingredient under the name Glucuronolactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Glucurolactone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Glucurolactone used outside industrial chemicals?
Glucurolactone also appears in cosmetics, pharmaceutical, cannabis databases.