Is Genistein Methyl Ether (Biochanin A) safe in cosmetics?
Genistein Methyl Ether (Biochanin A) has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Genistein Methyl Ether (Biochanin A)
Also known as: EINECS 207-744-7, UNII-U13J6U390T, 5,7-Dihydroxy-4'-methoxy-Isoflavone, 5,7-Dihydroxy-4'-methoxy-Isoflavone (8CI), 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one (+3 more)
INCI: GENISTEIN METHYL ETHER
Genistein Methyl Ether (Biochanin A) (CAS 491-80-5) is a cosmetic cosmetic ingredient functioning as Humectant; skin conditioning; skin protecting. EU Regulation 1223/2009 status: restricted, max 0.007%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 491-80-5 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant; skin conditioning; skin protecting
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
5,7-dihydroxy-3-(4-methoxyphenyl)chromen-4-one
InChIKey
WUADCCWRTIWANL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.007%
US US Status
permitted
US Notes
Permitted — no CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Genistein Methyl Ether (Biochanin A).
Calculate MoS for your specific formulation with the MoS Calculator.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα, ERβ
LOEC: 1 nM
EU status: allowed
agonist (ERβ-selective)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Genistein Methyl Ether (Biochanin A).
Known Synonyms
EINECS 207-744-7
UNII-U13J6U390T
5,7-Dihydroxy-4'-methoxy-Isoflavone
5,7-Dihydroxy-4'-methoxy-Isoflavone (8CI)
5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
5,7-dihydroxy-3-p-methoxyphenyl-4H-chromen-4-one
Biochanine a
pratensol
Chemical Function
Humectant
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BIOCHANIN
ChEMBL ID
CHEMBL131921
Frequently Asked Questions
Is Genistein Methyl Ether (Biochanin A) allowed in the EU?
Genistein Methyl Ether (Biochanin A) EU regulatory status: restricted. Maximum allowed concentration: 0.007%. This is based on EU Regulation 1223/2009 and its amendments.
What does Genistein Methyl Ether (Biochanin A) do in cosmetics?
Genistein Methyl Ether (Biochanin A) functions as: Humectant; skin conditioning; skin protecting. It is classified as a cosmetic ingredient in our database. CAS number: 491-80-5.
Is Genistein Methyl Ether (Biochanin A) used outside cosmetics?
Genistein Methyl Ether (Biochanin A) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Genistein Methyl Ether (Biochanin A) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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