Is Gamma-Undecalactone safe in cosmetics?
Gamma-Undecalactone has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Gamma-Undecalactone
Also known as: Undecanoic acid, 4-hydroxy-, γ-lactone, Aldehyde C-14 peach, BRN 0081943, EINECS 203-225-4, FEMA No. 3091 (+10 more)
INCI: GAMMA-UNDECALACTONE
Gamma-Undecalactone (CAS 104-67-6) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient, perfuming agent. NOAEL 112 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 104-67-6 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient, perfuming agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
5-heptyloxolan-2-one
InChIKey
PHXATPHONSXBIL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS status No. 3091; listed as substance added to food; no specific FDA restrictions in cosmetics; EPA TSCA inventory listed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Gamma-Undecalactone.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Gamma-Undecalactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 14 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Gamma-Undecalactone across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1296 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
233
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
gamma-UNDECALACTONE | 1997 | 0-1.25 mg/kg bw (1967) | No safety concern at current levels of intake when used as a flavouring agent. The 1967 ADI of 0-1.25 mg/kg bw was maintained at the forty-ninth meeting (1997). | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PEACH ALDEHYDE | 1997 | 0-1.25 mg/kg bw (1967) | No safety concern at current levels of intake when used as a flavouring agent. The 1967 ADI of 0-1.25 mg/kg bw was maintained at the forty-ninth meeting (1997). | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Softener and conditioner
Solvent
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Gamma-Undecalactone.
Regulatory Flags
fragrance
lactone
cramer-class-i
peach-note
ifra-unrestricted
readily-biodegradable
fema-gras
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Gamma-Undecalactone by CAS number or substance name.
Studies
1
Lowest NOAEL
14 mg/kg bw/day
Highest NOAEL
14 mg/kg bw/day
COSMOS_DB
Known Synonyms
Undecanoic acid, 4-hydroxy-, γ-lactone
Aldehyde C-14 peach
BRN 0081943
EINECS 203-225-4
FEMA No. 3091
1,4-Hendecanolide
gamma-Heptyl-gamma-butyrolactone
gamma-n-Heptylbutyrolactone
Peach aldehyde
gamma-Undecanolactone
gamma-Undecanolide
1,4-Undecanolide
delta-Undecalactone
gamma-Undekalakton
UNII-QB1T0AG2YL
Chemical Function
Fragrance
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL195827
Frequently Asked Questions
Is Gamma-Undecalactone allowed in the EU?
Gamma-Undecalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Gamma-Undecalactone do in cosmetics?
Gamma-Undecalactone functions as: Fragrance ingredient, perfuming agent. It is classified as a cosmetic ingredient in our database. CAS number: 104-67-6.
What is the NOAEL for Gamma-Undecalactone?
The NOAEL (No Observed Adverse Effect Level) for Gamma-Undecalactone is 14 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Is Gamma-Undecalactone used outside cosmetics?
Gamma-Undecalactone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Gamma-Undecalactone compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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