What is the NOAEL for 5-Heptyldihydro-2(3H)-furanone?
5-Heptyldihydro-2(3H)-furanone has 17 NOAEL studies in the database. The lowest reported value is 1.25 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
REACH Registered
Cosmetic Ingredient
5-Heptyldihydro-2(3H)-furanone
Also known as: Undecanoic acid, 4-hydroxy-, γ-lactone, Aldehyde C-14 peach, BRN 0081943, EINECS 203-225-4, FEMA No. 3091 (+11 more)
CAS 104-67-6
5-Heptyldihydro-2(3H)-furanone (CAS 104-67-6) is a chemical substance. Key regulatory status: REACH registered, 24 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
17
SOURCE
chemical inventory jurisdictions
Regulatory lists
24
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
22 fields
Name
5-Heptyldihydro-2(3H)-furanone
CAS Number
104-67-6
DTXSID
DTXSID4034287
Molecular Formula
C11H20O2
InChI Key
PHXATPHONSXBIL-UHFFFAOYSA-N
Monoisotopic Mass
184.14633
Synonyms
Undecanoic acid, 4-hydroxy-, γ-lactoneAldehyde C-14 peachBRN 0081943EINECS 203-225-4FEMA No. 30911,4-Hendecanolidegamma-Heptyl-gamma-butyrolactonegamma-n-HeptylbutyrolactonePeach aldehydegamma-Undecanolactonegamma-Undecanolide1,4-Undecanolide
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceSoftener and conditionerSolventDeodorizerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
24 records
| List | Keyword | Source |
|---|---|---|
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| active_ingredient; Pesticides | MN Department of Agriculture Pesticide Sales Database | CPCat |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Europe | European Commission | Fl@vis |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 17 of 17 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=1.25 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| 9.47 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =19 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| QB1T0AG2YL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QB1T0AG2YL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QB1T0AG2YL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QB1T0AG2YL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.069 | fraction | Fu | - | Human | NTP_ICE_adme_parameters |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =18500 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 14 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =112 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =112 | mg/kg bw/day | NOAEL | oral: gavage | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 17 of 17 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Undecan-4-olide | 203-225-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Essential Oils
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL195827
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
2
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: 0-1.25 mg/kg bw (1967) mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 5-Heptyldihydro-2(3H)-furanone?
5-Heptyldihydro-2(3H)-furanone appears on 7 regulatory/inventory lists including active_ingredient; Pesticides, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 4 more. Source: EPA CPDat.
Is 5-Heptyldihydro-2(3H)-furanone used in cosmetics?
Yes, 5-Heptyldihydro-2(3H)-furanone is also indexed as a cosmetic ingredient under the name Gamma-Undecalactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 5-Heptyldihydro-2(3H)-furanone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 5-Heptyldihydro-2(3H)-furanone used outside industrial chemicals?
5-Heptyldihydro-2(3H)-furanone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.