Is Farnesal safe in cosmetics?
Farnesal has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Farnesal
Also known as: 2,6,10-Dodecatrienal, 3,7,11-trimethyl-, 3,7,11-Trimethyl-2,6,10-dodecatrienal, Farnesone, DODECA-2,6,10-TRIENAL, 3,7,11-TRIMETHYL-, 3,7,11-trimethyldodeca-2,6,10-trien-1-al (+1 more)
INCI: FARNESAL
Farnesal (CAS 19317-11-4) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 19317-11-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3,7,11-trimethyldodeca-2,6,10-trienal
InChIKey
YHRUHBBTQZKMEX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — no specific 21 CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Farnesal.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
22.85%
DPRA Lys %
14.85%
GHS: inconclusive
Source: DPRA: ECVAM Validation Study Report
IFRA Concentration Limits (12 Product Categories)
International Fragrance Association standards per product category. Restriction: Restriction. Effective: 2021-02-10.
| Category | Max % | Category | Max % |
|---|---|---|---|
| 1 (Lip products) | 0.005% | 7a (Deodorant – not spray) | 0.0099% |
| 2 (Body spray) | 0.0015% | 7b (Deodorant spray) | 0.0099% |
| 3 (Body cream) | 0.005% | 8 (Face cream) | 0.0017% |
| 4 (Fine fragrance) | 0.02% | 9 (Soap) | 0.025% |
| 5a (Body lotion) | 0.005% | 10a (Household – non-spray) | 0.025% |
| 5b (Face cream leave-on) | 0.005% | 10b (Household – spray) | No Restriction% |
| 5c (Hand cream) | 0.005% | 11a (Intimate – leave-on) | 0.0017% |
| 5d (Baby cream) | 0.0017% | 11b (Intimate – rinse) | 0.0017% |
| 6 (Mouthwash) | 0.005% | 12 (Not for consumer exposure) | No Restriction% |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1228
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3,7,11-TRIMETHYL-2,6,10-DODECATRIENAL | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">RS 952-JECFA 69/149 | ">FAS 60-JECFA 69/628
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
FARNESAL | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">RS 952-JECFA 69/149 | ">FAS 60-JECFA 69/628
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Farnesal.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
2,6,10-Dodecatrienal, 3,7,11-trimethyl-
3,7,11-Trimethyl-2,6,10-dodecatrienal
Farnesone
DODECA-2,6,10-TRIENAL, 3,7,11-TRIMETHYL-
3,7,11-trimethyldodeca-2,6,10-trien-1-al
3,7,11-Trimethyldodeca-2,6,10-trienal
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Farnesal allowed in the EU?
Farnesal EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Farnesal do in cosmetics?
Farnesal functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 19317-11-4.
Compliance Tools
Check Farnesal compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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