Good Fragrance NOAEL Data

Eucalyptus Oil (Eucalyptus Globulus Leaf Oil)

Also known as: Eucalyptus oil, Oils, eucalyptus, Caswell No. 618A, EPA Pesticide Chemical Code 040503, Eucalyptus absolute (+13 more)

INCI: EUCALYPTUS GLOBULUS LEAF OIL

Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) (CAS 8000-48-4) is a cosmetic fragrance functioning as Skin Conditioning. Reported NOAEL =100 mg/kg bw/day in rat (CIR_vision_codex); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.

View industrial chemical safety profile for CAS 8000-48-4 →

Auto-generated CPSR Part A draft with source citations
CAS Number
8000-48-4
View industrial chemical safety profile →
Function
Skin Conditioning
Safety Rating
GOOD

Chemistry & Identifiers

UNII: 2R04ONI662 Wikidata: Q511687

Regulatory Status

EU EU Status restricted
US US Status permitted
US Notes Reference 21 CFR 341.40(u)

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Eucalyptus Oil (Eucalyptus Globulus Leaf Oil).

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Eucalyptus Oil (Eucalyptus Globulus Leaf Oil). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =100 mg/kg bw/day - rat NOAEL study CIR_vision_codex
NOAEL =100 mg/kg bw/day - rat NOAEL study CIR_vision_codex
NOAEL =100 mg/kg bw/day - rat NOAEL study CIR_vision_codex
NOAEL =100 mg/kg bw/day - rat NOAEL study CIR_vision_codex
NOAEL =300 mg/kg oral rat oral toxicity CIR_vision_codex
NOAEL =300 mg/kg oral rat oral toxicity CIR_vision_codex
NOAEL =300 mg/kg oral rat oral toxicity CIR_vision_codex
NOAEL =300 mg/kg oral rat oral toxicity CIR_vision_codex
NOAEL =1000 mg/kg oral rat oral toxicity CIR_vision_codex
NOAEL =1000 mg/kg oral rat oral toxicity CIR_vision_codex

EPA ToxValDB — Toxicity Values

3 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint Value Species Route Duration Source
LD50 <5000 mg/kg Rabbit dermal acute ECHA IUCLID
LD50 =2480 mg/kg Rabbit dermal acute ECHA IUCLID
LD50 =2480 mg/kg Rat oral - TEST

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

Additional Jurisdictional Restrictions (1)
Jurisdiction Status Max % Product Type
CA restricted 25% All cosmetics

Additional Ingredient Properties

1 property record from structured ingredient metadata.

depigmentation
{"cas_number": "8000-48-4", "ingredient_class": "anti_inflammatory_brightener", "primary_mechanism_of_action": "Aromatic compounds reduce inflammation and PIH", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-30", …

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Biocide Deodorizer Flavouring and nutrient Fragrance Humectant Pharmaceutical Softener and conditioner
Regulatory List Membership (5)
EU Regulated in Personal Care EU Restricted for Children (Cosmetics) IFRA Fragrance Transparency List FDA Substances Added to Food (EAFUS) Consumer Product Chemical

Expert Verdict

Expert safety assessment and concern-level summary for Eucalyptus Oil (Eucalyptus Globulus Leaf Oil).

Regulatory Flags

EU Restricted eu_children_restricted ifra_fragrance fda_food_additive

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) by CAS number or substance name.

Studies
12
Lowest NOAEL
100
Highest NOAEL
1000

Units vary across source rows: mg/kg bw/day, mg/kg

CIR_vision_codex

Known Synonyms

Eucalyptus oil Oils, eucalyptus Caswell No. 618A EPA Pesticide Chemical Code 040503 Eucalyptus absolute Eucalyptus citriodora Eucalyptus citriodora distillate Eucalyptus globulus oil Eucalyptus oil citriodora FEMA No. 2466 Oil eucalyptus globulus or macarthuri Essential oils, eucalyptus Oils, essential, eucalyptus Essential eucalyptus oil Eucalyptus terpene oil Eukalyptus oel UNII-2R04ONI662 UNII-M63U6N96EB

Chemical Function

Fragrance

Regulatory Lists

IFRA Transparency IFRA Transparency consumer_product IFRA Transparency IFRA Transparency IFRA Transparency Europe; Personal care Europe; Personal care Europe; Personal care Europe; Personal care children; Europe; Personal care children; Europe; Personal care - specialized bath products - bubble bath IFRA Transparency active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical and food safety data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA count match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Adverse Event Associations
26
View full pharmaceutical profile →
SOURCE EFSA / FDA GRAS food_additives

Food Safety Data

Same-CAS food additive or FDA GRAS records from the core public database.

Food Name
EUCALYPTUS, OIL (EUCALYPTUS GLOBULUS LABILLE)
Food Category
flavoring
View full food safety profile →

Frequently Asked Questions

Is Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) safe in cosmetics?

Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.

Is Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) allowed in the EU?

Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) do in cosmetics?

Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) functions as: Skin Conditioning. It is classified as a Fragrance in our database. CAS number: 8000-48-4.

What is the NOAEL for Eucalyptus Oil (Eucalyptus Globulus Leaf Oil)?

The NOAEL (No Observed Adverse Effect Level) for Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) is =100 mg/kg bw/day based on a NOAEL study study via oral route in rat. A total of 10 study endpoints are available. Source: CIR_vision_codex.

Is Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) used outside cosmetics?

Eucalyptus Oil (Eucalyptus Globulus Leaf Oil) also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Compliance Tools

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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